Association between accelerated biological aging and colorectal cancer: a cross-sectional study.

Background: Biological age (BA) is regarded as a more accurate marker of aging than chronological age and is commonly used to assess associations with age-related diseases. The relationship between BA measures and the colorectal cancer (CRC) has not yet been investigated.

Methods: This study utilized data from the National Health and Nutrition Examination Survey.

Joule-Heating-Driven Encapsulation of FeCo Nanoparticles in Ion-Selective Carbon Shell for Stable Seawater Electrolysis.

The oxygen evolution reaction (OER) in seawater is notoriously hindered by slow kinetics and high overpotential, compounded by chloride-induced corrosion, which impedes efficient hydrogen production via seawater electrolysis. A key challenge is to devise an OER catalyst that not only mitigates chlorine oxidation and corrosion but is also cost-effective. In this work, the bimetallic iron-cobalt (FeCo) nanoparticles are swiftly encapsulated within N-doped carbon shells in mere seconds using the Joule-heating technique, a process significantly faster than the several hours required by traditional furnace heating.

Clinical and Multiorgan Proteomics Characteristics of the Diverse Fatal Phase in Super Elderly Patients With SARS-CoV-2 Infection: A Descriptive Study.

This study aims to identify the risk factors associated with clinical outcomes and the proteomic changes in organs related to fatal SARS-CoV-2 infection within the super-elderly population. This retrospective analysis included all elderly individuals with COVID-19 admitted to the Second Medical Center of PLA General Hospital from December 2022 to January 2023. The follow-up period ended on March 30, 2023.

CD271 regulates osteogenic differentiation of ectomesenchymal stem cells via the RhoA/ROCK signaling pathway.

The low-affinity neurotrophic receptor CD271 plays a crucial role in the osteogenic differentiation of ectomesenchyme stem cells (EMSCs), which is essential for the development and regeneration of jaw bones. This study aimed to investigate the influence of CD271 on EMSCs osteogenic differentiation and to uncover the underlying mechanisms. CD271-deficient mice exhibited delayed mandibular bone development, with a significantly reduction in the expression of osteogenic makers such as ALP, Col-1, OPN, and RUNX2.

New insights into the role of ubiquitination in angiogenesis (Review).

Angiogenesis is a dynamic and complex mechanism for generating new blood vessels from existing ones. Angiogenesis occurs through all life stages and involves several physiological processes. It has an important physiological and pathological role including in cancer, wound healing and inflammation.

Mapping the susceptibility to freeze-thaw deterioration and regionalization of freeze-thaw environments of earthen sites in China: A preliminary study.

Earthen sites in China are widely exposed to freeze-thaw environments. There is a lack of knowledge about the spatial distribution patterns of freeze-thaw deterioration and environments, as well as preventive conservation strategies and subsequent refined research on the freeze-thaw deterioration of earthen sites. In this study, the freeze-thaw deterioration process of earthen sites was divided into two periods.

The potential therapeutic role of curcumin in osteoporosis treatment: based on multiple signaling pathways.

Osteoporosis is a common chronic metabolic bone disease caused by disturbances in normal bone metabolism and an imbalance between osteoblasts and osteoclasts. Osteoporosis is characterized by a decrease in bone mass and bone density, leading to increased bone fragility. Osteoporosis is usually treated with medications and surgical methods, but these methods often produce certain side effects.

Tetracycline Three Times Daily Versus Four Times Daily in Bismuth-Containing Quadruple Therapy as the First-Line Treatment of Helicobacter pylori Infection: A Multicenter, Noninferiority, Randomized Controlled Trial.

Background: Current guidelines recommend bismuth-containing quadruple therapy for patients newly diagnosed with Helicobacter pylori (H. pylori) infection. We aimed to compare the efficacy and safety of tetracycline administered three times daily versus four times daily in bismuth-containing quadruple therapy for first-line treatment of H.

Inhibition of miR-9 Combined With Cisplatin Targeting APE1 Against Angiogenesis in Osteosarcoma.

Osteosarcoma (OS) is a highly malignant tumor, and chemotherapy resistance suggests poor prognosis in OS patients. In this study, the authors discovered that miR-9 has a pro-angiogenic role in OS. The anti-angiogenic effects of cisplatin were greatly increased when miR-9 was suppressed in OS.

Three species of rape responded to cadmium and melatonin alleviating Cd-toxicity in species-specific strategy.

Cadmium (Cd) pollution has been a significant concern in heavy metal pollution, prompting plants to adopt various strategies to mitigate its damage. While the response of plants to Cd stress and the impact of exogenous melatonin has received considerable attention, there has been limited focus on the responses of closely related species to these factors. Consequently, our investigation aimed to explore the response of three different species of rape to Cd stress and examine the influence of exogenous melatonin in this scenario.

Solution-Processed Metallic Nanowire Network for Wearable Transparent Thermal Radiation Shield.

Heating requirements for residential and commercial dwellings result in significant energy consumption and deleterious environmental effects. Personal radiative thermal management textiles regulate the wearer's body temperature by controlling the material's intrinsic optical properties. Passive heating textiles suppress radiative heat losses and therefore significantly reduce the energy consumption required for building heating systems.

Antiviral effectiveness and survival correlation of azvudine and nirmatrelvir/ritonavir in elderly severe patients with COVID-19: a retrospective real-world study.

Background: Azvudine and nirmatrelvir/ritonavir are approved to treat mild-to-moderate coronavirus disease 2019 (COVID-19) in adults with a high risk for progression to severe infection. We sought to compare the antiviral effectiveness and clinical outcomes of elderly severe patients with COVID-19 receiving these two antiviral agents.

Methods: In this observational study, we identified 249 elderly patients with severe COVID-19 infection who were admitted to the Second Medical Center of the People's Liberation Army General Hospital from December 2022 to January 2023, including 128 azvudine recipients, 66 nirmatrelvir/ritonavir recipients and 55 patients not received antiviral treatments.

Multivalence-State Tungsten Species Facilitated Iridium Loading for Robust Acidic Water Oxidation.

The development of the proton exchange membrane water electrolyzer (PEMWE) is still limited by the prohibitive cost and scarcity of iridium (Ir)-based oxygen evolution reaction (OER) catalyst. This work presents a novel catalyst synthesized by precursor-atomization and rapid joule-heating method, successfully doping iridium atoms into polyvalent tungsten blends (W, W, W) based on titanium substrate. The vacancy engineering of unsaturated tungsten oxide (W, W) reconstructs the electronic structure of the catalyst surface, which resulting in the low-valence state iridium species, avoiding excessive oxidation of iridium and accelerating the catalytic kinetics.

Epigallocatechin gallate alleviates osteoporosis by regulating the gut microbiota and serum metabolites in rats.

Osteoporosis, one of the serious public health problems worldwide, can lead to degeneration of the bone structure and increased risk of fractures. Epigallocatechin gallate (EGCG) is a natural product with potential efficacy in inhibiting bone loss. However, the specific mechanism remains unclear.

The synergistic effects of polyphenols and intestinal microbiota on osteoporosis.

Osteoporosis is a common metabolic disease in middle-aged and elderly people. It is characterized by a reduction in bone mass, compromised bone microstructure, heightened bone fragility, and an increased susceptibility to fractures. The dynamic imbalance between osteoblast and osteoclast populations is a decisive factor in the occurrence of osteoporosis.

Ultra-Fast Recyclable and Value-Added Desulfation Method for Spent Lead Paste via Dual Intensification Processes.

The new low-cost clean pre-desulfation technology is very important in pyrometallurgy and hydrometallurgy. However, traditional reactors have low space-time yield and desulfation rate, resulting in high energy consumption and SO emissions in the industrial desulfation processes. Herein, dual rotating liquid film reactors (RLFRs) and lime are proposed to construct a recyclable, ultra-fast, and value-added desulfation method.

Prognostic value of baseline C-reactive protein in diffuse large B-cell lymphoma: a systematic review and meta-analysis.

Background: C-reactive protein (CRP) is an inflammatory marker of great significance for progression and prognosis of diffuse large B-cell lymphoma (DLBCL). However, previous studies reported the inconsistent findings of the relationship between CRP levels and survival in DLBCL patients. This meta-analysis was performed to investigate the predictive value of baseline CRP in the prognosis of DLBCL.

Discovery of a heterotrophic aerobic denitrification Pseudomonas sp. G16 and its unconventional nitrogen metabolic pathway.

From the aerobic pond of the farm, the Pseudomonas sp. G16 was screened and isolated, which was confirmed to exhibit heterotrophic nitrification and aerobic denitrification. The removal rates of Ammonia (100 mg/L), nitrate (120 mg/L), and nitrite (100 mg/L) by the strain were 94.

Combined with multiplex and network analysis to reveal the key genes and mechanisms of nonalcoholic fatty liver disease.

Background And Aims: Non-alcoholic fatty liver disease (NAFLD) has become a significant cause of chronic liver disease in developed countries, as a result of the worldwide trend of obesity and associated metabolic syndrome. Obesity and high-fat diet (HFD) are very common in patients with NAFLD. However, how to screen out key differentially expressed genes (DEGs) is a challenging task.

Clinical Characteristics and Survival Analysis of Patients With Second Primary Malignancies After Hepatocellular Carcinoma Liver Transplantation: A SEER-based Analysis.

Background: Second primary malignancies (SPMs) after liver transplantation (LT) are becoming the leading causes of death in LT recipients. The purpose of this study was to explore prognostic factors for SPMs and to establish an overall survival nomogram.

Methods: A retrospective analysis was conducted of data from the Surveillance, Epidemiology, and End Results (SEER) database on adult patients with primary hepatocellular carcinoma who had undergone LT between 2004 and 2015.

Gastrointestinal digestibility of micellar casein dispersions: Effects of caprine vs bovine origin, and partial colloidal calcium depletion using in vitro digestion models for the adults and elderly.

In vitro coagulation and digestion of caprine and bovine micellar casein concentrate (MCC) with or without partial colloidal calcium depletion (deCa) were studied under simulated adult and elderly conditions. Gastric clots were smaller and looser for caprine than bovine MCC, and were further looser with deCa and under elderly condition for both caprine and bovine MCC. Casein hydrolysis and concomitant formation of large peptides was faster for caprine than bovine MCC, and with deCa and under adult condition for caprine and bovine MCC.