Publications by authors named "Keyla V M Xavier"
Prevalence of cagA, cagM, vacA and oipA genes in isolates of Helicobacter pylori obtained from hospital patients in Northeast Brazil.
Thaynara Millena de Oliveira Bezerra Keyla Vitória Marques Xavier Ana Carolina de Oliveira Luz Isabella Macário Ferro Cavalcanti Carlos Alexandre Antunes de Brito
Braz J Microbiol
September 2024
Article Synopsis
- Helicobacter pylori is linked to serious gastrointestinal issues like chronic gastritis, peptic ulcers, and gastric cancer, affecting about half the world's population, especially in underdeveloped countries.
- A study in Recife analyzed 147 patients and found a 48% infection rate of H. pylori, mainly in females over 46, with histological exams revealing conditions beyond chronic gastritis.
- The virulence genes cagA, cagM, vacA, and oipA were detected in significant portions of the infected samples, but no specific genetic markers were associated with severity, suggesting a need for further research with larger groups.
CRISPR/Cas is a molecular mechanism to prevent predatory viruses from invading bacteria via the insertion of small viral sequences (spacers) in its repetitive locus. The nature of spacer incorporation and the viral origins of spacers provide an overview of the genetic evolution of bacteria, their natural viral predators, and the mechanisms that prokaryotes may use to protect themselves, or to acquire mobile genetic elements such as plasmids. Here, we report on the CRISPR/Cas genetic structure, its spacer content, and strain epidemiology through MLST and CRISPR typing in , an opportunistic pathogen intimately related to hospital infections and antimicrobial resistance.
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