Receiving financial support and its association with late-age depression: The mediating role of social engagement.

Objectives: Researchers have long been concerned with the association between family financial support and depression in older adults. However, it remains unclear whether social engagement influences the relationship between depression and financial support in later life. Therefore, this study aims to examine the relationship between receiving financial support from family and others and depression among Indian older adults and to also explore the mediating effect of social engagement on this relationship.

Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly.

Glioblastoma, the most lethal primary brain tumor, harbors glioma stem cells (GSCs) that not only initiate and maintain malignant phenotypes but also enhance therapeutic resistance. Although frequently mutated in glioblastomas, the function and regulation of PTEN in PTEN-intact GSCs are unknown. Here, we found that PTEN directly interacted with MMS19 and competitively disrupted MMS19-based cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) machinery in differentiated glioma cells.

Displacement identification of oil storage tank and calibration of tank capacity table model based on indicator function integral.

Based on the indicator function integral, this paper identifies the displacement of oil storage tank and calibrates the tank capacity table model. The displacement parameters of a cylinder oil tank with spherical caps at both ends are deduced by establishing an appropriate rectangular coordinate system while cross-section analysis, coordinate transformation, and the functional relationship between oil reserves and oil level height are used as well. Furthermore, the displacement parameters are determined by the least square method and alternating contraction search method to verify the data, which improves the accuracy of the calculation.

Wastewater treatment and reuse situations and influential factors in major Asian countries.

As Asia is the most populous continent in the world, the contradiction between water supply and demand is increasing. Wastewater treatment and reclaimed water use are important means to solve the contradiction between supply and demand and realize the sustainability of the water management system. Based on the data collected from 48 typical countries and regions in Asia, this study evaluates the possible influential factors on wastewater treatment and reclaimed water use such as Gross Domestic Product (GDP) level, water resource availability, water withdrawn and water stress.

Corrigendum to "Modeling Inhibitory Effect on the Growth of Uninfected T Cells Caused by Infected T Cells: Stability and Hopf Bifurcation".

[This corrects the article DOI: 10.1155/2018/3176893.].

Modeling Inhibitory Effect on the Growth of Uninfected T Cells Caused by Infected T Cells: Stability and Hopf Bifurcation.

We consider a class of viral infection dynamic models with inhibitory effect on the growth of uninfected T cells caused by infected T cells and logistic target cell growth. The basic reproduction number is derived. It is shown that the uninfected equilibrium is globally asymptotically stable if < 1.

Protection of pancreatic beta-cells by group VIA phospholipase A(2)-mediated repair of mitochondrial membrane peroxidation.

Mitochondrial production of reactive oxygen species and oxidation of cardiolipin are key events in initiating apoptosis. We reported that group VIA Ca(2+)-independent phospholipase A(2) (iPLA(2)beta) localizes in and protects beta-cell mitochondria from oxidative damage during staurosporine-induced apoptosis. Here, we used iPLA(2)beta-null (iPLA(2)beta(-/-)) mice to investigate the role of iPLA(2)beta in the repair of mitochondrial membranes.

[Expression of iPLA2 in human pancreatic islets and its important role in glucose-stimulated insulin secretion].

Objective: To assess the role of calcium-independent phospholipase A2 (iPLA2) in human pancreatic islets.

Methods: The immunohistochemical analysis and Western blot were employed to examine iPLA2 expression in human pancreatic islets. Bromoenol lactone (BEL), a selective inhibitor of iPLA2, was used in a randomized controlled trial to compare its influence to glucose-stimulated insulin secretion.

[A dopaminergic projection from the dorsal raphe nucleus to the inner ear].

Objective: To investigate the efferent pathway from the dorsal raphe nucleus to the inner ear.

Methods: Eleven adult cats weighing 2.0 - 3.

Calcium-independent phospholipase A2 localizes in and protects mitochondria during apoptotic induction by staurosporine.

Mitochondria-mediated production of reactive oxygen species (ROS) plays a key role in apoptosis. Mitochondrial phospholipid cardiolipin molecules are likely the main target of ROS because they are particularly rich in polyunsaturated fatty acids. They are also located in the inner mitochondrial membrane near the ROS-producing sites.

Disruption of G1-phase phospholipid turnover by inhibition of Ca2+-independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase.

The G1 phase of the cell cycle is characterized by a high rate of membrane phospholipid turnover. Cells regulate this turnover by coordinating the opposing actions of CTP:phosphocholine cytidylyltransferase and the group VI Ca2+-independent phospholipase A2 (iPLA2). However, little is known about how such turnover affects cell-cycle progression.

Insulin resistance and type 2 diabetes in high-fat-fed mice are linked to high glycotoxin intake.

Dietary advanced glycosylation end products (AGEs) have been linked to insulin resistance in db/db(++) mice. To test whether dietary AGEs play a role in the progression of insulin resistance in normal mice fed high-fat diets, normal C57/BL6 mice were randomly assigned to high-fat diets (35% g fat), either high (HAGE-HF group; 995.4 units/mg AGE) or low (by 2.

Inhibition of Ca2+-independent phospholipase A2 results in insufficient insulin secretion and impaired glucose tolerance.

Islet Ca2+-independent phospholipase A2 (iPLA2) is postulated to mediate insulin secretion by releasing arachidonic acid in response to insulin secretagogues. However, the significance of iPLA2 signaling in insulin secretion in vivo remains unexplored. Here we investigated the physiological role of iPLA2 in beta-cell lines, isolated islets, and mice.

Elevated vascular endothelial growth factor production in islets improves islet graft vascularization.

Successful islet transplantation depends on the infusion of sufficiently large quantities of islets, of which only approximately 30% become stably engrafted. Rapid and adequate revascularization of transplanted islets is important for islet survival and function. Delayed and insufficient revascularization can deprive islets of oxygen and nutrients, resulting in islet cell death and early graft failure.