A small interfering RNA inhibits lung fibroblast-myofibroblast differentiation via simultaneously knockingdown CELF1 and activating RIG-I signalling.

Fibroblast-myofibroblast differentiation plays a key role in the pathogenesis of pulmonary fibrosis. Integrating RNA interference and RNA immunostimulation functions to treat diseases is a promising new potential therapy. Here, we report that an elevated expression of CUGBP Elav-Like Family Member 1 (CELF1), an RNA-binding protein, positively correlates with lung fibroblast-myofibroblast differentiation in fibrotic lung tissues.