Treatment of Secondary Full-Thickness Macular Holes with Topical Therapy.

Purpose: To report the outcomes of secondary full-thickness macular holes (FTMHs) treated with topical therapy.

Design: Retrospective case series.

Participants: Patients with secondary FTHMs initially treated with topical therapy in a referral-based retina practice.

Near-infrared reflectance bull's eye maculopathy as an early indication of hydroxychloroquine toxicity.

Importance: In some patients, hydroxychloroquine ocular toxicity may progress even following cessation of therapy. Any leverage the clinician may use to allow earlier detection may avert significant vision loss.

Observation: We report three cases suggesting that bull's eye maculopathy seen on near-infrared reflectance with a confocal scanning laser ophthalmoscope could be an early, objective manifestation of hydroxychloroquine ocular toxicity, and with progression of the disease this near-infrared "bull's eye" change may disappear.