Gas1-Mediated Suppression of Hepatoblastoma Tumorigenesis.

Hepatoblastoma (HB), the most common pediatric liver cancer, is associated with dysregulated Wnt/β-catenin, Hippo, and/or nuclear factor erythroid 2 ligand 2/nuclear respiratory factor 2 (NFE2L2/NRF2) pathways. In mice, pairwise combinations of oncogenically active forms of the terminal transcription factors of these pathways, namely, β-catenin (B), Yes-associated protein (YAP; Y), and Nrf2 (N), generated HBs, with the triple combination (B + Y + N) being particularly potent. Each tumor group alters the expression of thousands of B-, Y-, and N-driven unique and common target genes.

Immunotherapy in Recurrent Ovarian Cancer.

Background/objectives: It remains challenging to treat recurrent ovarian cancer effectively as traditional interventions like chemotherapy and surgery have limited long-term efficacy, highlighting an urgent need for innovative approaches. Immunotherapy offers potential advantages in modulating the immune response against tumor cells and has emerged as a promising strategy in ovarian cancer management. This review discusses various immunotherapy modalities, including active and passive immune strategies, for recurrent ovarian cancer.

Detection of meteorological influence on bread wheat quality in Hebei province, China based on the gradient boosting decision tree.

Wheat grain quality is equivalent to grain yield in terms of ensuring food security under climate change but has received less attention. Identifying critical meteorological conditions in key phenological periods to account for the variability in grain protein content (GPC) can provide insight into linkages between climate change and wheat quality. The wheat GPC data from different counties of Hebei Province, China during 2006-2018 and corresponding observational meteorological data were used in our study.

Achieving Tunable Organic Afterglow and UV-Irradiation-Responsive Ultralong Room-Temperature Phosphorescence from Pyridine-Substituted Triphenylamine Derivatives.

Amorphous polymers with ultralong room-temperature phosphorescence (RTP) are highly promising for various applications. Particularly, polymer-based RTP materials with multiple functions such as color-tunability or stimulus-response are highly desirable for multilevel anti-counterfeiting but are rarely reported. Herein, a facile strategy is presented to achieve a series of polymer-based RTP materials with ultralong lifetime, multicolor afterglow, and reversible response to UV irradiation by simply embedding pyridine-substituted triphenylamine derivatives into the polymer matrix poly(vinyl alcohol) (PVA) and poly(methyl methacrylate) (PMMA), respectively.

PM Pollution: Health and Economic Effect Assessment Based on a Recursive Dynamic Computable General Equilibrium Model.

At present particulate matter (PM) pollution represents a serious threat to the public health and the national economic system in China. This paper optimizes the whitening coefficient in a grey Markov model by a genetic algorithm, predicts the concentration of fine particulate matter (PM), and then quantifies the health effects of PM pollution by utilizing the predicted concentration, computable general equilibrium (CGE), and a carefully designed exposure-response model. Further, the authors establish a social accounting matrix (SAM), calibrate the parameter values in the CGE model, and construct a recursive dynamic CGE model under closed economy conditions to assess the long-term economic losses incurred by PM pollution.

Indirect Economic Impact Incurred by Haze Pollution: An Econometric and Input-Output Joint Model.

Econometrics and input-output models have been presented to construct a joint model (i.e., an EC + IO model) in the paper, which is characterized by incorporating the uncertainty of the real economy with the detailed departmental classification structure, as well as adding recovery period variables in the joint model to make the model dynamic.

PM Pollution and Inhibitory Effects on Industry Development: A Bidirectional Correlation Effect Mechanism.

In this paper, a vector autoregression (VAR) model has been constructed in order to analyze a two-way mechanism between PM pollution and industry development in Beijing via the combination of an impulse response function and variance decomposition. According to the results, long-term equilibrium interconnection was found between PM pollution and the development of primary, secondary, and tertiary industries. One-way Granger causalities were found in the three types of industries shown to contribute to PM pollution, though the three industries showed different scales of influences on the PM pollution that varied for about 1⁻2 years.

[The effect of total phenolics from abnormal savda munziq on cervical cancer cell lines].

Objective: To explore the feasibility of total phenolics from Abnormal Savda Munziq on treating human cervical carcinoma.

Methods: MTT assay was used to determine the growth inhibition ratio and IC50 on Hela cells and SiHa cells after treated with different concentrations of total phenolics. Morphologic changes of cells were observed by inverted microscope.