Different Cytotoxicity Induced by Hexabromocyclododecanes on Mouse Neuroblastoma N2a Cells via Oxidative Stress and Mitochondrial Apoptotic Pathway.

Hexabromocyclododecane (HBCD) is widely used in polystyrene foams, building materials, and electrical equipment as a brominated flame retardant (BFR) and persists in the environment and human body matrix. It has attracted increased attention since its neuroendocrine disorder effects have been observed in humans and animals. However, studies evaluating the neurotoxicity of HBCD diastereoisomers and the potential mechanisms involved are still limited.

Technology-based interventions on burden of older adults' informal caregivers: a systematic review and meta-analysis of randomized controlled trials.

Background: An increasing number of technologies are provided to reduce the burden of older adults' informal caregivers. However, less is known about the effects and the mechanism of technology to work on burden. This review is to evaluate the effectiveness of technology-based interventions (TBI) in alleviating the burden of older adults' informal caregivers and to distinguish its effective mechanism via group disparities.

Mindfulness-based interventions to reduce anxiety among Chinese college students: A systematic review and meta-analysis.

Mindfulness-based interventions are found to have a positive effect on an individual's mental health. Using a meta-analysis method, this study examined the effects of mindfulness-based interventions on alleviating anxiety among Chinese college students. Using six international and two Chinese electronic databases, we comprehensively researched literature published between 1 January 2012 and 31 December 2021.

[Effects of hexabromocyclododecanes on retinoid X receptor α, pregnane X receptor and peroxisome proliferator-activated receptor γ].

Objective: To investigate the effect of hexabromocyclododecanes( HBCDs) on cell proliferation and the expression of the three important cell nuclear receptor of retinoic X receptor α( RXRα), peroxisome proliferator-activated receptor-γ( PPARγ), pregnane X receptor( PXR) and their interaction in Neuro-2a(N2a).

Methods: Neuro-2a cells were treated with different concentrations of diastereoisomers, of HBCDs which were α-HBCD, β-HBCD, γ-HBCD, respectively, and cell toxicity was analyzed using the cell counting kit-8( CCK-8) assay. The impact of HBCDs on cell cycles of Neuro-2a were analyzed by flow cytometry analysis, and the expression levels in mRNA and protein for the three nuclearreceptors( RXRα, PPARγ, PXR andits target genes CYP3A11) were determined by RT-PCR and Western blot, respectively.