Publications by authors named "Keyan Chai"
Article Synopsis
- - Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver condition in China linked to insulin resistance and genetics, prompting an analysis of traditional Chinese medicines alongside Western treatments to determine their effectiveness in improving liver health.
- - The study included 77 randomized controlled trials with 7770 patients, focusing on clinical efficacy rates and blood lipid levels as primary outcomes, using various statistical tools for analysis.
- - Results showed that Huazhi Rougan granules combined with Western medications had the highest efficacy rate (81.7%) and significantly improved blood lipids, while Danning tablets were most effective when used alone, demonstrating high clinical efficacy as well.
Background: Combining antitumor proprietary Chinese medicine (pCm) with radiotherapy and chemotherapy can effectively improve tumor cure rates and enhance patients' quality of life. Gastric cancer (GC) severely endangers public health. Despite satisfactory therapeutic effects achieved by using antitumor pCm to treat GC, its underlying mechanism remains unclear.
View Article and Find Full Text PDFBackground: Respiratory tract infections (RTIs) are characterized by a high mortality rate and clinical incidence. Bairui granules (BG), which employ a method of heat elimination and detoxification, have demonstrated benefits in the treatment of infectious respiratory diseases.
Methods: A computerized search of 6 databases was conducted to identify randomized controlled trials (RCTs) relevant to the treatment of RTIs with BG up to November 30, 2023.
Article Synopsis
- Malignant pleural effusion (MPE) is a common complication in advanced cancers, and lentinan for injection (LNT) has been found to improve patients' quality of life and survival rates.
- A meta-analysis of 52 randomized controlled trials showed that combining LNT with cisplatin significantly enhances treatment effectiveness and quality of life while reducing gastrointestinal side effects.
- The findings suggest that LNT combined with cisplatin is a more effective treatment for MPE without increasing adverse drug reactions, highlighting its potential for clinical use.
Background: Acute pharyngitis (AP) refers to the acute inflammation of the pharynx, characterized by swelling and pain in the throat. Shuangyang houbitong granules (SHG), a traditional Chinese medicine compound, have been found to be effective in providing relief from symptoms associated with AP.
Methods: The chemical components of SHG were screened using Traditional Chinese Medicine Systems Pharmacology database, HERB database, and China National Knowledge Infrastructure.
Article Synopsis
- - This study conducted a meta-analysis to assess the safety and effectiveness of Lentinan (LNT) when used alongside chemotherapy for patients with gastric cancer, analyzing data from 31 randomized controlled trials involving 2729 participants.
- - Results showed that patients receiving LNT had significantly improved treatment outcomes, including better overall efficacy and an enhanced quality of life, along with some notable immune system benefits compared to those on chemotherapy alone.
- - No serious side effects were reported with the LNT treatment, indicating it could be a viable complementary therapy; however, more research is needed to confirm these findings.
Biotransformation and metabolism of three methyl salicylate glycosides by gut microbiota in vitro.
J Pharm Biomed Anal
September 2023
MSTG-A, MSTG-B and Gualtherin are three natural methyl salicylate glycosides isolated from Dianbaizhu (Gaultheria leucocarpa var. yunnanensis), which is a traditional Chinese folk medicine widely used for the treatment of rheumatoid arthritis. They share the same mother nucleus with aspirin, exhibit similar activity and have fewer side effects.
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