Ultra-selective recognition of UO triggering its intrinsic luminescence using a precisely designed europium metal-organic framework.

A novel method for highly selective recognition of UO is proposed based on a [Eu(pyridine-2,5-dicarboxylic acid -oxide)] (Eu-PDA) metal-organic framework. Benefiting from the unique chemical structure of Eu-PDA, energy transfer from PDA to UO was enabled, resulting in the highly up-regulated fluorescence of UO. The Eu-PDA probe showed excellent specificity to UO over numerous interfering species, as the intrinsic emissions of UO were triggered.

Potential predictive role of Non-HDL to HDL Cholesterol Ratio (NHHR) in MASLD: focus on obese and type 2 diabetic populations.

Introduction: This cross-sectional study was conducted to examine the association between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and metabolic dysfunction-associated steatotic liver disease (MASLD), particularly in populations with obesity and type 2 diabetes (T2D).

Methods: The analysis included 3784 participants who were 20 years and older, using data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018. The prevalence of MASLD was determined using multivariable logistic regression analysis, which calculated odds ratios (ORs) and 95% confidence intervals (CIs).

Identification of R2R3-MYB Transcription Factor Family Based on Genome and Promoting Betalain Biosynthesis by Directly Activating Expression.

MYB (myeloblastosis) is one of the most abundant transcription factors in plants which regulates various biological processes. The molecular characteristics and function of R2R3-MYB transcription factors in amaranth remain unclear. In this study, 73 R2R3-MYB members were identified from the amaranth genome database and we further analyzed their chromosome position, conserved motifs, physiological and biochemical features, collinearity relationships, gene structure, phylogeny and -acting element.

IG-Net: An Instrument-guided real-time semantic segmentation framework for prostate dissection during surgery for low rectal cancer.

Background And Objective: Accurate prostate dissection is crucial in transanal surgery for patients with low rectal cancer. Improper dissection can lead to adverse events such as urethral injury, severely affecting the patient's postoperative recovery. However, unclear boundaries, irregular shape of the prostate, and obstructive factors such as smoke present significant challenges for surgeons.

Acoustic characteristics of infant- and foreigner-directed speech with Mandarin as the target language.

The quality of speech input influences the efficiency of L1 and L2 acquisition. This study examined modifications in infant-directed speech (IDS) and foreigner-directed speech (FDS) in Standard Mandarin-a tonal language-and explored how IDS and FDS features were manifested in disyllabic words and a longer discourse. The study aimed to determine which characteristics of IDS and FDS were enhanced in comparison with adult-directed speech (ADS), and how IDS and FDS differed when measured in a common set of acoustic parameters.

Site-recognition boosted the sensing performance of terbium-based organic frameworks for UO detection.

A unique fluorescent sensing probe for UO detection was fabricated with terbium-based metal organic frameworks introducing specific recognition sites (denoted as Tb-TDPAT). The newly formed Tb-TDPAT presented remarkable detection sensitivity and selectivity towards UO, surpassing the need for complex post-modification methods.

Serum selenium and fasting blood glucose: a cross-sectional study in women of different menopause status.

Background: This cross-sectional study aims to explore whether there exists an interaction between selenium and menopause concerning type 2 diabetes (T2D) prevalence and its related indicators such as fasting blood glucose (FBG) and homeostasis model assessment of insulin resistance (HOMA-IR).

Methods: 150 women aged 35-60 years old were finally analyzed in this study. Multivariate linear or logistic regression modeling was conducted to explore the association of selenium and the prevalence of T2D besides its related indicators.

Impact of age, sex, and thyroid autoimmunity on the association between selenium intake and type 2 diabetes mellitus.

Background: The association between dietary selenium(Se) intake and type 2 diabetes mellitus (T2DM) remains controversial. The present study aimed to investigate this association using data from the National Health and Nutrition Examination Survey (NHANES) database for the years 2007-2012.

Methods: Three thousand seventy three individuals aged 20 years and above were eligible for inclusion in this cross-sectional study.

Research progress of SWI/SNF complex in breast cancer.

In the past decade, numerous epigenetic mechanisms have been discovered to be associated with cancer. The mammalian SWI/SNF complex is an ATP-dependent chromatin remodeling complex whose mutations are associated with various malignancies including breast cancer. As the SWI/SNF complex has become one of the most commonly mutated complexes in cancer, targeting epigenetic mutations acquired during breast cancer progress is a potential means of improving clinical efficacy in treatment strategies.

Organoboron flank-substituted donor-acceptor polymer anode with ultra-long cycling stability for lithium ion batteries.

The tunable structure and other properties of organic materials suggest that they can potentially solve the shortcomings of traditional anodes such as graphite. We successfully introduced an organoboron unit into the thiophene-based polymer PBT-2 to construct a donor-acceptor polymer anode. The charge delocalization and LUMO energy level resulting from the unique structure of this material enabled good redox activity and a very stable electrochemical performance in electrochemical tests, with a reversible capacity of 262 mA h g at 0.

Short-and long-term outcomes of one-stage versus two-stage gastrectomy for perforated gastric cancer: a multicenter retrospective propensity score-matched study.

Objective: There is no scientific consensus about the treatment of perforated gastric cancer (PGC). Therefore, the aim of this study was to investigate which is the better treatment option for PGC between the single-stage and two-stage strategies.

Methods: All 81 PGC patients from 13 medical institutions were retrospectively enrolled in this study.

Interaction analysis of high-risk pathological features on adjuvant chemotherapy survival benefit in stage II colon cancer patients: a multi-center, retrospective study.

Background: We aimed to analyze the benefit of adjuvant chemotherapy in high-risk stage II colon cancer patients and the impact of high-risk factors on the prognostic effect of adjuvant chemotherapy.

Methods: This study is a multi-center, retrospective study, A total of 931 patients with stage II colon cancer who underwent curative surgery in 8 tertiary hospitals in China between 2016 and 2017 were enrolled in the study. Cox proportional hazard model was used to assess the risk factors of disease-free survival (DFS) and overall survival (OS) and to test the multiplicative interaction of pathological factors and adjuvant chemotherapy (ACT).

Cercospora leaf spot disease of sugar beet.

Leaf spot disease caused by Sacc. is the most damaging foliar disease threatening sugar beet production worldwide. The wide spread of disease incurs a reduction of yield and economic losses.

Surgical site infection after intracorporeal and extracorporeal anastomosis in laparoscopic left colectomy for colon cancer: a multicenter propensity score-matched cohort study.

Background: Intracorporeal anastomosis (IA) is associated with reduced surgical site infection (SSI) and other postoperative complications in laparoscopic right colectomy (LRC). However, evidence is inadequate for IA in laparoscopic left colectomy (LLC). This study aimed to determine the effect of IA and extracorporeal anastomosis (EA) on SSI and other short-term postoperative complications in LLC.

Establishment of Surgical Difficulty Grading System and Application of MRI-Based Artificial Intelligence to Stratify Difficulty in Laparoscopic Rectal Surgery.

(1) Background: The difficulty of pelvic operation is greatly affected by anatomical constraints. Defining this difficulty and assessing it based on conventional methods has some limitations. Artificial intelligence (AI) has enabled rapid advances in surgery, but its role in assessing the difficulty of laparoscopic rectal surgery is unclear.

Knockout of cyclase-associated protein CAP1 confers tolerance towards salt and osmotic stress in Arabidopsis.

As a regulator of actin filament turnover, Arabidopsis thaliana CAP1 plays an important role in plant growth and development. Here, we analyzed the phenotypes of two Arabidopsis cap1 mutants: cap1-1 (a T-DNA insertion mutant) and Cas9-CAP1 (generated by CRISPR-Cas9 gene editing). Phenotypic analysis demonstrated that loss of CAP1 results in defects in seed germination and seedling morphology, with some seedlings exhibiting one or three cotyledons.

Efficient elimination of phenazone by an electro-assisted Fe-EDDS/PS process at neutral pH: Kinetics, mechanistic insights and toxicity evaluation.

The feasibility of the degradation of phenazone (PNZ), a common anti-inflammatory drug used for reducing pain and fever, in water at neutral pH by an electrochemically assisted Fe-ethylenediamine disuccinate-activated persulfate process (EC/Fe-EDDS/PS) was investigated. The efficient removal of PNZ at neutral pH condition was mainly attributed to the continuous activation of PS via electrochemically driven regenerated Fe from a Fe-EDDS complex at the cathode. The influence of several critical parameters, including current density, Fe concentration, EDDS to Fe molar ratio, and PS dosage, on PNZ degradation was evaluated and optimized.

Risk Factors of Isolated Microtia: A Systematic Review and Meta-Analysis.

Background: Isolated microtia is a congenital facial anomaly, and its cause is unclear. This study systematically investigated related suspicious factors.

Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines.

CARK3-mediated ADF4 regulates hypocotyl elongation and soil drought stress in Arabidopsis.

Actin depolymerization factors (ADFs), as actin-binding proteins, act a crucial role in plant development and growth, as well as in response to abiotic and biotic stresses. Here, we found that CARK3 plays a role in regulating hypocotyl development and links a cross-talk between actin filament and drought stress through interaction with ADF4. By using bimolecular fluorescence complementation (BiFC) and GST pull-down, we confirmed that CARK3 interacts with ADF4 and .

A green-inspired method to prepare non-split high-density lipoprotein (HDL) carrier with anti-dysfunctional activities superior to reconstituted HDL.

Numerous studies have demonstrated that dysfunctional high-density lipoprotein (HDL), especially oxidized HDL (OxHDL), could generate multifaceted in vivo proatherogenic effects that run counter to the antiatherogenic activities of HDL. It thereby reminded us that the in vitro reconstituted HDL (rHDL) might encountered with oxidation-induced dysfunction. Accordingly, a green-inspired method was employed to recycle non-split HDL from human plasma fraction IV.

Evidence Summary for Nonpharmacological Management of Chemotherapy-Induced Nausea and Vomiting.

Objective: To evaluate and summarize the best evidence for nonpharmacological management of chemotherapy induced nausea and vomiting (CINV). This article aims at serving as a reference for nursing staff to prevent and manage CINV.

Methods: We systematically searched for evidence on CINV in databases such as Cnki and Wanfang, guide websites such as GIN and NZGG, and professional websites such as UICC and ACS.

Timing of MeCP2 Expression Determines Midbrain Dopamine Neuron Phenotype Specification.

Midbrain dopamine (DA) neurons are associated with locomotor and psychiatric disorders. DA phenotype is specified in ancestral neural precursor cells (NPCs) and maintained throughout neuronal differentiation. Here we show that endogenous expression of MeCP2 coincides with DA phenotype specification in mouse mesencephalon, and premature expression of MeCP2 prevents in vitro cultured NPCs from acquiring DA phenotype through interfering NURR1 transactivation of DA phenotype genes.