Publications by authors named "Kexin Xian"
The myocardial wall arises from a single layer of cardiomyocytes, some delaminate to create trabeculae while others remain in the compact layer. However, the mechanisms governing cardiomyocyte fate decisions remain unclear. Using single-cell RNA sequencing, genetically encoded biosensors, and in toto live imaging, we observe intrinsic variations in expression and its association with trabecular fate.
View Article and Find Full Text PDFSubstantial epigenetic resetting during early embryo development from fertilization to blastocyst formation ensures zygotic genome activation and leads to progressive cellular heterogeneities. Mapping single-cell epigenomic profiles of core histone modifications that cover each individual cell is a fundamental goal in developmental biology. Here we develop target chromatin indexing and tagmentation (TACIT), a method that enabled genome-coverage single-cell profiling of seven histone modifications across mouse early embryos.
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- Epstein-Barr virus (EBV) infection is linked to various cancers, but the role of EB nuclear antigen 1 binding protein 2 (EBNA1BP2) in tumors is not well understood, prompting an investigation into its potential as a prognostic biomarker across multiple cancer types.
- Utilizing extensive bioinformatics analyses on data from TCGA and GEO databases, the study assessed EBNA1BP2's expression, prognostic significance, immune infiltration, and methylation levels in pan-cancer.
- Results indicated that higher EBNA1BP2 expression is seen in tumor tissues, with lower levels correlating to better survival rates in specific cancers; it also plays roles in cell cycle regulation, DNA repair, and immune cell