Angew Chem Int Ed Engl
February 2025
The progress of mRNA therapeutics underscores the imperative demand for the development of targeted delivery systems. While cationic polymers hold promise as genetic vectors, their poor in vivo efficacy and numerous variants highlight the urgent need for a universal functionalization strategy to bolster their delivery capabilities. Here, we present a versatile strategy to transform low-cost commercial cationic polymers into phospholipidated and alkylated polymers (PAPs), enabling efficient and organ-selective mRNA delivery in vivo.
View Article and Find Full Text PDFfabricated polyether electrolytes have been regarded as one of the most promising solid electrolyte systems. Nevertheless, they cannot match high-voltage cathodes over 4.3 V due to their poor oxidative stability.
View Article and Find Full Text PDFJ Control Release
December 2024
Angew Chem Int Ed Engl
June 2024
Unlocking the full potential of mRNA immunotherapy necessitates targeted delivery to specific cell subsets in the spleen. Four-component lipid nanoparticles (LNPs) utilized in numerous clinical trials are primarily limited in hepatocyte and muscular targeting, highlighting the imperative demand for targeted and simplified non-liver mRNA delivery systems. Herein, we report the rational design of one-component ionizable cationic lipids to selectively deliver mRNA to the spleen and T cells with high efficacy.
View Article and Find Full Text PDFHerein we report a novel methodology for the ex situ generation of SFCl by employing 4,4'-dipyridyl disulfide as a safe commercial reagent, obviating the need for lecture bottles. The method is applicable to certain SFCl-involving transformations by using a two-chamber reactor. Moreover, easily applying SFCl in different solvents is rendered feasible, while avoiding the use of glovebox techniques.
View Article and Find Full Text PDFRNA-based therapeutics have shown great promise in various medical applications, including cancers, infectious diseases, and metabolic diseases. The recent success of mRNA vaccines for combating the COVID-19 pandemic has highlighted the medical value of RNA drugs. However, one of the major challenges in realizing the full potential of RNA drugs is to deliver RNA into specific organs and tissues in a targeted manner, which is crucial for achieving therapeutic efficacy, reducing side effects, and enhancing overall treatment efficacy.
View Article and Find Full Text PDFThe present study aims to investigate the mechanism of the nature compound gambogenic acid (GNA) on the apoptosis and ferroptosis in colorectal cancer (CRC). The effect of GNA on the proliferation of CRC cell lines were detected by MTT and clonogenic assay. The xenograft tumor model was established, and the inhibition effect of GNA were evaluated by observing the tumor growth.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
July 2023
Sulfur(VI)-fluoride exchange (SuFEx) chemistry, an all-encompassing term for substitution events that replace fluoride at an electrophilic sulfur(VI), enables the rapid and flexible assembly of linkages around a S core. Although a myriad of nucleophiles and applications works very well with the SuFEx concept, the electrophile design has remained largely SO -based. Here, we introduce S≡N-based fluorosulfur(VI) reagents to the realm of SuFEx chemistry.
View Article and Find Full Text PDFCurr Cancer Drug Targets
August 2023
The sarcoma virus oncogene (Src) tyrosine kinase, a nonreceptor protein-tyrosine kinase, plays a crucial role in cell survival, migration, differentiation and proliferation. The study of Src has developed considerably since it was first discovered as a proto-oncogene. Src has also been associated with inflammation and bone-related diseases.
View Article and Find Full Text PDFGastric cancer (GC) is one of the most common malignancies, and it has become the third most common malignant tumour in the world. Targeting metastasis has also become a key and difficult point in the treatment of GC. Solasodine is an active ingredient isolated from Solanum nigrum L.
View Article and Find Full Text PDFActa Crystallogr E Crystallogr Commun
March 2023
The title compound, CHBrNOS, is the bromo-benzene-sulfonamide derivative of the type 2 diabetes drug metformin. The asymmetric unit contains two mol-ecules with almost identical conformations but a different orientation of the bromo-phenyl moiety. Both mol-ecules exhibit intra-molecular N-H⋯N and N-H⋯O hydrogen bonds.
View Article and Find Full Text PDFMicroplastic (MP) pollution has increasingly become an enormous global challenge due to the ubiquity and uncertain environmental performance, especially for nano- and micro- sized MPs. In this work, the performance and mechanisms in coagulation of 100 nm-5.0 μm sized polystyrene particles using an etherified starch-based coagulant (St-CTA) assisted by polysilicic acid (PSA) were systematically studied on the basis of the changes in MPs removal rates under various pH levels and in the presence of different coexisting inorganic and organic substances, zeta potentials of supernatants, and floc properties.
View Article and Find Full Text PDFBackground: Depression plays a significant role in mediating breast cancer recurrence and metastasis. However, a precise risk model is lacking to evaluate the potential impact of depression on breast cancer prognosis. In this study, we established a depression-related gene (DRG) signature that can predict overall survival (OS) and elucidate its correlation with pathological parameters and sensitivity to therapy in breast cancer.
View Article and Find Full Text PDFThe administration of nanoparticles (NPs) first faces the challenges of evading renal filtration and clearance of reticuloendothelial system (RES). After that, NPs infiltrate through the expanded endothelial space and penetrated the dense stroma of tumor microenvironment to tumor cells. As long as possible to prolong the time of NPs remaining in tumor tissue, NPs release active agent and induce pharmacological action.
View Article and Find Full Text PDFAn efficient Rh-catalyzed ortho-acrylation reaction for the synthesis of chalcones from O-methyl ketoximes and cyclopropenones via C-H bond activation has been described. This cross-coupling reaction exhibits high functional group tolerance and regioselectivity. A wide range of chalcone derivatives are obtained in moderate to good yields under mild conditions.
View Article and Find Full Text PDFMater Sci Eng C Mater Biol Appl
November 2019
Metals such as Ta (tantalum) and Ti (titanium) have been popularly used as a bone substitute or implants in orthopedic surgery and dentistry, since they have excellent corrosion. For manufacturing porous implants with precise structure, SLM (Selective laser melting), which is one of the 3D (three-dimensional) printing techniques, is always be chosen. To compare biological performances between porous Ta and Ti implants, we designed them with the same porosity, pore shape, pore size, and pore distribution via CAD (computer aided design), and then produced them by SLM.
View Article and Find Full Text PDFA properly designed porous scaffold can accelerate the osseointegration process, and the use of computer-aided design (CAD) and additive manufacturing (AM) techniques has the potential to improve the traditional porous scaffold approach. In this study, we evaluate the effect of porous TiAlV (Ti) with different pore structures on osteointegration and osteogenesis. Porous Ti scaffolds with different pore structures based on four commercially available implants were designed and manufactured by CAD and selective laser melting (SLM).
View Article and Find Full Text PDFHua Xi Kou Qiang Yi Xue Za Zhi
June 2018
Objective: This work aims to investigate the effect of porous tantalum and porous titanium on osseointegration.
Methods: Two kinds of porous materials with same microporous parameters, namely, porous tantalum and porous titanium, were fabricated by computer-aided design (CAD) modeling and 3D printing technology. A defect model was established in 24 New Zealand white rabbits in the bilateral femoral lateral malleolus at the left and right side of each animal.
Maxillofacial injuries can be complex and are clinically important due to their functional and cosmetic significance. Maltreated and missed fractures might cause deformity of the face; thus, accurate evaluation of the fracture provided by X-ray images is critical. In this study, we explore the application of cone-beam computed tomography (CBCT) for diagnosis of severe maxillofacial traumas.
View Article and Find Full Text PDFPrevious studies have demonstrated that cancer cells with increased levels of aldehyde dehydrogenase 'bright' activity (ALDH) exhibit stem cell properties compared with cells exhibiting decreased ALDH activity (ALDH). To screen possible biomarkers of cancer stem cells in tongue squamous cell carcinoma, ALDH and ALDH cells were isolated from the tongue squamous cell carcinoma TCA8113 cell line, and suppression subtractive hybridization was performed to identify differentially expressed genes in the two subpopulations. A total of 240 positive clones were randomly selected for sequencing and were functionally characterized using bioinformatical tools.
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