Publications by authors named "Kexin Pang"
Background: Snijders Blok-Campeau syndrome (SNIBCPS) is a rare genetic disorder characterized by facial abnormalities, hypotonia, macrocephaly, and global developmental delay (GDD) caused by mutations in gene. There is limited information on SNIBCPS and few studies on its pathogenic gene .
Methods: We utilized whole-exome sequencing, minigene splicing assay analysis, and construction of protein models to validate the suspected pathogenic mutation.
Article Synopsis
- Jia-Wei-Kai-Xin-San (JWKXS) was studied for its potential effects on mild cognitive impairment (MCI) in SAMP8 mice, which could help delay the progression of Alzheimer's disease.
- The results showed that JWKXS treatment for 8 weeks improved learning and memory abilities, reduced brain damage, and identified key pathways involved in its mechanism, including inhibition of neuroinflammation and apoptotic processes.
- While the study indicates positive outcomes, limitations like small sample size and short treatment duration suggest the need for further research to explore JWKXS's full effects and mechanisms against MCI.