Finite-time prescribed performance tracking control for nonlinear time-delay systems with state constraints and actuator hysteresis.

In this paper, the problem of adaptive neural network prescribed performance tracking control for a class of non-strict feedback time-delay systems constrained by full-state is studied. Radial basis function (RBF) neural networks (NNs) are integrated into the backstepping medium to deal with the uncertain functions and the barrier Lyapunov function (BLF) technique ensures that the state of the system does not exceed its limits. Subsequently, integrated with the Lyapunov-Krasovskii functional, the proposed control scheme makes the tracking errors converge to the preset region while the state constraint is not violated.

Polydopamine-Based Targeted Nanosystem for Chemo/Photothermal Therapy of Retinoblastoma in a Mouse Orthotopic Model.

Background: At present, the few photothermal/chemotherapy studies about retinoblastoma that have been reported are mainly restricted to ectopic models involving subcutaneous implantation. However, eyeball is unique physiological structure, the blood-retina barrier (BRB) hinders the absorption of drug molecules through the systemic route. Moreover, the abundant blood circulation in the fundus accelerates drug metabolism.

The association between declining lung function and stroke risk: insights from an observational study and Mendelian randomization.

Background: Stroke, prevalent globally, particularly impacts low- and middle-income countries. Decreased lung function is one of the risk factors for stroke, and there is a lack of sufficient research on the association between the two, especially based on evidence from representative large samples. We aimed to explore the association between lung function and stroke incidence.

Long-term impact of PM exposure on frailty, chronic diseases, and multimorbidity among middle-aged and older adults: insights from a national population-based longitudinal study.

Particulate Matter 2.5 (PM) is a significant risk factor for frailty and chronic diseases. Studies on the associations between PM and frailty, chronic diseases, and multimorbidity are scarce, especially from large cohort studies.

Frailty index trajectories in Chinese older adults with diverse levels of social participation: findings from a national population-based longitudinal study.

Background: Aging and frailty pose significant challenges globally, placing a substantial burden on healthcare and social services due to their adverse consequences.

Aim: The primary objective of this study was to investigate the relationship between social participation and development of frailty transition and trajectory.

Methods: This study utilized data from the CLHLS Cohort, a 10-year follow-up study involving 6713 participants, to investigate the association between social participation and development of frailty.

Deep Learning-Based Road Traffic Noise Annoyance Assessment.

With the development of urban road traffic, road noise pollution is becoming a public concern. Controlling and reducing the harm caused by traffic noise pollution have been the hot spots of traffic noise management research. The subjective annoyance level of traffic noise has become one of the most important measurements for evaluating road traffic pollution.

Manipulation of sterol homeostasis for the production of 24-epi-ergosterol in industrial yeast.

Brassinolide (BL) is the most biologically active compound among natural brassinosteroids. However, the agricultural applications are limited by the extremely low natural abundance and the scarcity of synthetic precursors. Here, we employ synthetic biology to construct a yeast cell factory for scalable production of 24-epi-ergosterol, an un-natural sterol, proposed as a precursor for BL semi-synthesis.

Speciation analysis and formation mechanism of iron-phosphorus compounds during chemical phosphorus removal process.

Iron (Fe) salt was applied extensively to remove phosphorus (P) in wastewater treatment plants (WWTPs). Exploring the formation mechanism of iron-phosphorus compounds (FePs) during the chemical P removal (CPR) process is beneficial to P recovery. In this study, the performance of P removal, FePs speciation analysis and the kinetics of P removal under different conditions (pH, Fe/P molar ratio (Fe/P), type of Fe salt, dissolved organic matters) were comprehensively investigated.

Synthesis and Biological Evaluation of Novel Allobetulon/Allobetulin-Nucleoside Conjugates as AntitumorAgents.

Allobetulin is structurally similar tobetulinic acid, inducing the apoptosis of cancer cells with low toxicity. However, both of them exhibited weak antiproliferation against several tumor cell lines. Therefore, the new series of allobetulon/allobetulin-nucleoside conjugates - were designed and synthesized for potency improvement.

Understanding roles of humic substance and protein on iron phosphate transformation during anaerobic fermentation of waste activated sludge.

Effects of fulvic acid (FA) and bovine serum albumin (BSA) on the transformation of ferric phosphate (FePO) during anaerobic fermentation of waste activated sludge were investigated. Both FA and BSA promoted phosphorus (P) release from FePO. A higher P release efficiency was achieved with FA addition compared with BSA at the same dose although BSA promoted iron (Fe) reduction more effectively.

Ca mobilization and signaling pathways induced by rRgpB in human gingival fibroblast.

: To assess the () recombinant gingivalis gingipain R2 (rRgpB)-induced Ca mobilization in human gingival fibroblast (HGF) mediated by protease-activated receptor (PAR) and its downstream signal transduction pathways. : Flow cytometry was used to detect the expression of PAR in HGF. The proliferation of HGF was measured by CCK-8.

Spatial Distribution Characteristics and Pollution Evaluation of Soil Iron in the Middle Hanjiang River.

Soil iron has an important impact on the ecological environment and on crop growth. This study selected a typical small watershed basin in the middle reaches of the Han River (Yujiehe) at Ankang City and used geostatistical methods and kriging interpolation to analyze the spatial distribution and structure of soil iron content for different land uses and at different depths, using the single-factor pollution evaluation to evaluate the pollution degree of soil iron. The results showed that soil iron in the Yujie River basin decreased with increasing soil depth, with contents of 8.

Activation of calcium signaling in human gingival fibroblasts by recombinant Porphyromonas gingivalis RgpB protein.

Arginine-specific cysteine proteinases, such as Arg-gingipain B (RgpB), mediate inflammation by activating protease-activated receptors (PARs). Arg-gingipain B is produced by Porphyromonas gingivalis, and is implicated in the causation of periodontal disease. The purpose of the present study was to observe the influence of recombinant RgpB protein (rRgpB) on PAR activation by monitoring intracellular Ca2+ ion concentration ([Ca2+]i) and inositol-1,4,5-triphosphate (IP3) levels in human gingival fibroblasts (HGFs).

Predicting the target genes of miRNAs in preterm via targetscore algorithm.

Compared with normal neonates, preterm infants have an immature immune system which causes them to have a higher morbidity rate and even death. In order to reduce the mortality of newborns, we need to find the target genes which affect the preterm and understand their mechanism. It has been verified that microRNA (miRNA)-200 and miRNA-182 are closely related to the incidence of preterm.

Runoff change and sediment source during rainstorms in an ecologically constructed watershed on the Loess Plateau, China.

The sediment-reducing effect of check dams and the safety issues following dam breaks are long-standing concerns. This study analyzed the runoff change and sediment source during rainstorms in a small watershed using a multivariate mixed model and a comparative analysis of watersheds. The problem of sediment loss from dammed farmland following check dam break during rainstorms was evaluated.

MicroRNA‑223 attenuates LPS‑induced inflammation in an acute lung injury model via the NLRP3 inflammasome and TLR4/NF‑κB signaling pathway via RHOB.

Acute lung injury (ALI) and the more severe acute respiratory distress syndrome are common and complex inflammatory lung diseases. MicroRNAs (miRs) have emerged as novel gene regulatory molecules, serving a crucial role in a variety of complex diseases, including ALI. In the present study, the anti‑inflammatory action of miR‑223 on inflammation in ALI was demonstrated and the possible mechanism was further examined.

Identification of key genes in endometrioid endometrial adenocarcinoma via TCGA database.

Background: Understanding the molecular mechanisms is important in development and therapy of endometrioid endometrial adenocarcinoma.

Objective: To identify key genes in endometrioid endometrial adenocarcinoma.

Methods: The data of mRNA, miRNA and DNA methylation were downloaded from The Cancer Genome Atlas (TCGA) database and differential analysis was performed.

Development and application of a rapid detection system for human papillomavirus and Herpes simplex virus-2 by loop-mediated isothermal amplification assay.

Human papillomavirus (HPV) infection is an important factor that causes cervical cancer and non-melanoma skin cancer (NMSC), while HSV-2 plays an important role when HR-HPV triggers the cancer. Thus, a quick and convenient assay in the detection of HPV and HSV-2in the screening of HPV and HSV-2 infection is required. Two respective HPV and HSV-2 detection methods were established based on loop-mediated isothermal amplification (LAMP) assay.