Microstructures of Directionally Solidified NbTiFe Alloy and Its Hydrogen Permeation Properties in the Presence of HS.

Currently, the main limitations of Pd-coated Nb-TiFe dual-phase alloys include insufficient hydrogen permeability, susceptibility to hydrogen embrittlement (HE), and poor tolerance of HS poisoning. To address these issues, this study proposes a series of improvements. First, a novel NbTiFe alloy composed of a well-aligned Nb-TiFe eutectic was successfully prepared using directional solidification (DS) technology.

Do Rh-Hydride Phases Contribute to the Catalytic Activity of Rh Catalysts under Reductive Conditions?

Rh-hydride phases were believed to be key causes of the exceptional catalytic ability of Rh catalysts under H reductive conditions. Here, we utilize the large-scale machine-learning-based global optimization to explore millions of Rh bulk, surface, and nanoparticle structures in contact with H, which rules out the presence of subsurface/interstitial H in Rh and Rh-hydride phases as thermodynamically stable phases under ambient conditions. Instead, an exceptional Rh-H affinity is identified for surface Rh atoms in Rh nanoparticles that can accommodate a high concentration of adsorbed H, with the surface Rh to H ratio reaching ∼2.

Diverse Head-to-Tail Sequences in the Circular Genome of Human Bocavirus Genotype 1 among Children with Acute Respiratory Infections Implied the Switch of Template Chain in the Rolling-Circle Replication Model.

Head-to-tail sequences have been reported in human bocavirus (HBoV) 1-4. To reveal their features and functions, HBoV DNA was screened among respiratory specimens from pediatric patients with an acute respiratory infection (ARI) between April 2020 and December 2022, followed by HBoV genotyping. Head-to-tail sequences were detected using nested PCR, TA cloning, and Sanger sequencing, and these findings were confirmed by mNGS and amplicon sequencing.

Surfaced Mn-Mn Dimeric Sites Dictate CO Hydrogenation Activity and C Selectivity over MnRh Binary Catalysts.

Massive ethanol production has long been a dream of human society. Despite extensive research in past decades, only a few systems have the potential of industrialization: specifically, Mn-promoted Rh (MnRh) binary heterogeneous catalysts were shown to achieve up to 60% C oxygenates selectivity in converting syngas (CO/H) to ethanol. However, the active site of the binary system has remained poorly characterized.

Molecular Engineering of Pure Superoxide Radical Photogenerator for Hypoxia-Tolerant Tumor Theranostics.

Photodynamic therapy (PDT) is a promising cancer treatment, but limited oxygen supply in tumors (hypoxia) can hinder its effectiveness. This is because traditional PDT relies on Type-II reactions that require oxygen. Type-I photosensitizers (PSs) offer a promising approach to overcome the limitations of tumor photodynamic therapy (PDT) in hypoxic environments.

The therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction.

Objective: To explore the therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction.

Method: Patients with prolonged ventilator weaning and cardiac dysfunction were randomly allocated to receive conventional treatment (control group) or intravenous infusion of levosimendan for 24 h based on conventional treatment (levosimendan group). Weaning success rates were then compared between the two groups.

High-intensity interval training improves fatty infiltration in the rotator cuff through the β3 adrenergic receptor in mice.

Aims: Rotator cuff muscle atrophy and fatty infiltration affect the clinical outcomes of rotator cuff tear patients. However, there is no effective treatment for fatty infiltration at this time. High-intensity interval training (HIIT) helps to activate beige adipose tissue.

Effect of High-Intensity Interval Training on Fatty Infiltration After Delayed Rotator Cuff Repair in a Mouse Model.

Background: Fatty infiltration (FI) of the rotator cuff muscles is correlated with shoulder function and retear rates after rotator cuff repair. High-intensity interval training (HIIT) induces beige adipose tissue to express more uncoupling protein 1 (UCP1) to consume lipids. The beta-3 adrenergic receptor (β3AR) is located on adipocyte membrane and induces thermogenesis.

Electrochemical hydrogen evolution on Pt-based catalysts from a theoretical perspective.

Hydrogen evolution reaction (HER) by splitting water is a key technology toward a clean energy society, where Pt-based catalysts were long known to have the highest activity under acidic electrochemical conditions but suffer from high cost and poor stability. Here, we overview the current status of Pt-catalyzed HER from a theoretical perspective, focusing on the methodology development of electrochemistry simulation, catalytic mechanism, and catalyst stability. Recent developments in theoretical methods for studying electrochemistry are introduced, elaborating on how they describe solid-liquid interface reactions under electrochemical potentials.

One-Step Synthesis of a Non-Precious-Metal Tris (Fe/N/F)-Doped Carbon Catalyst for Oxygen Reduction Reactions.

Advancements in inexpensive, efficient, and durable oxygen reduction catalysts is important for maintaining the sustainable development of fuel cells. Although doping carbon materials with transition metals or heteroatomic doping is inexpensive and enhances the electrocatalytic performance of the catalyst, because the charge distribution on its surface is adjusted, the development of a simple method for the synthesis of doped carbon materials remains challenging. Here, a non-precious-metal tris (Fe/N/F)-doped particulate porous carbon material (2P-Fe-850) was synthesized by employing a one-step process, using 2-methylimidazole, polytetrafluoroethylene, and FeCl as raw materials.

IL1RAP Knockdown in LPS-Stimulated Normal Human Astrocytes Suppresses LPS-Induced Reactive Astrogliosis and Promotes Neuronal Cell Proliferation.

The reactivation of astrocytes plays a critical role in spinal cord injury (SCI) repairment. In this study, IL1RAP expression has been found to be upregulated in SCI mice spinal cord, SCI astrocytes, and LPS-stimulated NHAs. Genes correlated with IL1RAP were significantly enriched in cell proliferation relative pathways.

Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid.

Background: Osteoarthritis (OA) is a disease of joint degeneration and impaired function. Muscle atrophy, fatty infiltration, and fibrosis are degenerative features of muscle injury and predict poor outcomes in some degenerative and exercise-related injuries. Patients with glenohumeral joint OA usually have rotator cuff muscle degeneration, even though the rotator cuff is intact.

Correction: A highly active Z-scheme SnS/ZnSnO photocatalyst fabricated for methylene blue degradation.

[This corrects the article DOI: 10.1039/D2RA05519H.].

A highly active Z-scheme SnS/ZnSnO photocatalyst fabricated for methylene blue degradation.

Herein, a highly active Z-scheme SnS/ZnSnO photocatalyst is fabricated by a one-step hydrothermal route. The structure, composition, photoelectric and photocatalytic properties of the as-prepared photocatalysts are systematically researched. The results demonstrate that SZS-6 displays a good photocatalytic performance with an efficiency of 94.

Bimetallic Pt-Ni Nanoparticles Confined in Porous Titanium Oxide Cage for Hydrogen Generation from NaBH Hydrolysis.

Sodium borohydride (NaBH), with a high theoretical hydrogen content (10.8 wt%) and safe characteristics, has been widely employed to produce hydrogen based on hydrolysis reactions. In this work, a porous titanium oxide cage (PTOC) has been synthesized by a one-step hydrothermal method using NH-MIL-125 as the template and L-alanine as the coordination agent.

Effect of the Notch1-mediated PI3K-Akt-mTOR pathway in human osteosarcoma.

Purpose: Osteosarcoma is one of the most common malignant bone tumours in early adolescence. The incidence rate of osteosarcoma has stagnated over the past 30 years, highlighting the need to develop novel therapies. In osteosarcoma cells, Notch1 expression is absent, and the Notch1 pathway is related to cancer cell proliferation, apoptosis and autophagy.

Constructing defect-related subband in silver indium sulfide QDs via pH-dependent oriented aggregation for boosting photocatalytic hydrogen evolution.

Surface engineering of quantum dots (QDs) plays critical roles in tailoring carriers' dynamics of I-III-VI QDs via the interplay of QDs in aggregates or assembly, thus influencing their photocatalytic activities. In this work, an aqueous synthesis and the followed pH tuned oriented assembly method are developed to prepare network-like aggregates, dispersion, or sheet-like assembly of GSH-capped Silver Indium Sulfide (AIS). FTIR, DLS, and HRTEM investigation revealed that surface protonation or deprotonation of QDs occurred at pH < 6 or pH > 12 favors the formation of network-like aggregates with various defects or sheet-like assembly with perfect crystal lattice, respectively, via the surface charge induced interaction among AIS QDs.

Aqueous synthesis of composition-tuned defects in CuInSe nanocrystals for enhanced visible-light photocatalytic H evolution.

The composition and defect tolerance of CuInSe (CISe) quantum dots (QDs) provide a scaffold to design defects tailoring the elemental ratio or distributions for boosting photocatalytic H evolution (PHE). Herein, a ligand-assisted two-step aqueous method was developed to prepare defect CISe quantum dots for the first time. UV-vis, XPS, HRTEM, and HADDF investigations confirmed the typical double-absorption edges of copper vacancy defects and indium substituted at copper site defects in the structure constructed through initial synthesis tuned by Cu/In ratio and the ensued coarsening.

Stability and anion diffusion kinetics of Yttria-stabilized zirconia resolved from machine learning global potential energy surface exploration.

Yttria-stabilized zirconia (YSZ) is an important material with wide industrial applications particularly for its good conductivity in oxygen anion transportation. The conductivity is known to be sensitive to Y concentration: 8 mol. % YSZ (8YSZ) achieves the best performance, which, however, degrades remarkably under ∼1000 °C working conditions.

Cancer Therapy Based on Smart Drug Delivery with Advanced Nanoparticles.

Background: Cancer, as one of the most dangerous disease, causes millions of deaths every year. The main reason is the absence of an effective and thorough treatment. Drug delivery systems have significantly reduced the side-effect of chemotherapy.

MicroRNA-211/BDNF axis regulates LPS-induced proliferation of normal human astrocyte through PI3K/AKT pathway.

Spinal cord injury (SCI) makes a major contribution to disability and deaths worldwide. Reactive astrogliosis, a typical feature after SCI, which undergoes varying molecular and morphological changes, is ubiquitous but poorly understood. Reactive astrogliosis contributes to glial scar formation that impedes axonal regeneration.

miR-24 represses metastasis of human osteosarcoma cells by targeting Ack1 via AKT/MMPs pathway.

The expression levels of the protein tyrosine kinase Ack1 has been reported to be dysregulated in various cancers and involve in oncogenesis and progression. However, the expression and role of Ack1 in osteosarcoma remains unknown. In this study, we found that Ack1 were evidently upregulated in human osteosarcoma tissues and cell lines.

Hydrogen-rich saline injection into the subarachnoid cavity within 2 weeks promotes recovery after acute spinal cord injury.

Hydrogen can relieve tissue-damaging oxidative stress, inflammation and apoptosis. Injection of hydrogen-rich saline is an effective method for transporting molecular hydrogen. We hypothesized that hydrogen-rich saline would promote the repair of spinal cord injury induced by Allen's method in rats.

microRNA-143 is associated with the survival of ALDH1+CD133+ osteosarcoma cells and the chemoresistance of osteosarcoma.

This study investigated the role of miR-143 in the chemoresistance of osteosarcoma tumor cells and the associated mechanisms. Real-time PCR was used to measure miR-143 levels. Western blot was used to detect protein expression.