Publications by authors named "Kewen Deng"
Use of uterine electromyography in the prediction of preterm birth after transvaginal cervical cerclage.
BMC Pregnancy Childbirth
October 2024
Article Synopsis
- - Preterm birth (PTB) is a significant issue, accounting for around 35% of neonatal deaths, and cervical insufficiency (CI) often leads to PTB, necessitating cervical cerclage to prevent early delivery.
- - A study involving 69 women who underwent cervical cerclage and uterine electromyography (uEMG) revealed that PTB risk was linked to past PTB history and contraction frequency, with uEMG showing a strong predictive value (AUC of 0.766) for determining PTB risk after cerclage.
- - The findings suggest that uEMG can serve as an effective method for predicting PTB in patients after cervical cerclage by monitoring contraction frequencies
Whole-exome sequencing (WES) is frequently utilized in diagnosing reproductive genetic disorders to identify various genetic variants. Canonical ±1,2 splice sites are typically considered highly pathogenic, while variants at the 5' or 3' ends of exon boundaries are often considered synonymous or missense variants, with their potential impact on abnormal gene splicing frequently overlooked. In this study, we identified five variants located at the last two bases of the exons and two canonical splicing variants in five distinct families affected by reproductive genetic disorders through WES.
View Article and Find Full Text PDFBackground: Unexplained recurrent spontaneous abortion (URSA) is a common pregnancy complication and the etiology is unknown. URSA-associated lncRNAs are expected to be potential biomarkers for diagnosis, and might be related to the disease pathogenesis.
Objective: To investigate differential lncRNAs in peripheral blood of non-pregnant URSA patients and matched healthy control women and to explore the possible mechanism of differential lncRNAs leading to URSA.
The expression profile of circRNA and its potential regulatory targets in the placentas of severe pre-eclampsia.
Taiwan J Obstet Gynecol
November 2019
Objective: To determine the expression profiles of circular RNAs (circRNAs) of women with severe pre-eclampsia (sPE group) versus normal pregnancies (normal control group).
Materials And Methods: RNA-sequencing (RNA-seq) was conducted to characterize differentially expressed circRNAs and mRNAs in the placental tissues of women with sPE versus normal pregnancies. circRNA functions were predicted by Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) database analysis.