Mechanism for transmission and pathogenesis of carbapenem-resistant Enterobacterales harboring the carbapenemase IMP and clinical countermeasures.

Carbapenem-resistant Enterobacterales (CRE) are some of the most important pathogens causing infections, which can be challenging to treat. We identified four -carrying CRE isolates and collected clinical data. The transferability and stability of the plasmid were verified by conjugation, successive passaging, and plasmid elimination assays.

Molecular antibiotic resistance mechanisms and co-transmission of the and metallo-β-lactamase genes in carbapenem-resistant complex.

Carbapenem-resistant complex (CRECC) has increasingly emerged as a major cause of healthcare-associated infections, with colistin being one of the last-resort antibiotics of treatment. Mobile colistin resistance () is a member of a growing family of genes and has been reported to be an inducible gene encoding an acquired phosphoethanolamine transferase. Here, we collected 24 ECC strains from Chongqing, China from 2018 to 2021.

Molecular characterization of NDM-1-producing carbapenem-resistant complex from a tertiary hospital in Chongqing, China.

Background: The aim of this study was to clarify the molecular characterization of NDM-1-producing carbapenem-resistant complex (CREL) at a teaching hospital in Chongqing, China.

Methods: Antimicrobial susceptibility and resistance genes were analyzed. Epidemiological relationship was analyzed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST).

Microbial Characteristics and Genomic Analysis of an ST11 Carbapenem-Resistant Strain Carrying Conjugative Drug-Resistant Plasmid.

Background: The sequence type 11 (ST11) carbapenem-resistant (CRKP) carrying has been widespread all over the world, and it has been reported frequently in China. The located on the mobile genetic element brings tremendous pressure to control the spread and outbreak of resistant bacteria. Whole-genome sequencing (WGS) technology can comprehensively and in-depth display the molecular characteristics of drug-resistant bacteria, providing a basis for evaluating the genetic diversity within the CRKP genome.

Carbapenemase Production and Epidemiological Characteristics of Carbapenem-Resistant in Western Chongqing, China.

Background: This study aimed to determine the molecular characteristics of carbapenem-resistant (CRKP) isolates in a hospital in western Chongqing, southwestern China.

Methods: A total of 127 unique CRKP isolates were collected from the Yongchuan Hospital of Chongqing Medical University, identified using a VITEK-2 compact system, and subjected to microbroth dilution to determine the minimal inhibitory concentration. Enterobacteriaceae intergenic repeat consensus polymerase chain reaction and multilocus sequence typing were used to analyze the homology among the isolates.

An Outbreak of Carbapenem-Resistant in an Intensive Care Unit of a Major Teaching Hospital in Chongqing, China.

Background: Due to the critical condition and poor immunity of patients, the intensive care unit (ICU) has always been the main hospital source of multidrug-resistant bacteria. In recent years, with the large-scale use of antibiotics, the detection rate and mortality of carbapenem-resistant (CRKP) have gradually increased. This study explores the molecular characteristics and prevalence of CRKP isolated from the ICU ward of a tertiary hospital in China.

Antibiotic susceptibility and molecular analyses of clinical Enterobacter cloacae isolates in Eastern Heilongjiang Province, China.

Background: Enterobacter cloacae is an emerging opportunistic pathogen. We retrospectively conducted a study to assess antimicrobial susceptibility and investigated the Molecular characteristics of carbapenem-resistant Enterobacter cloacae (CREL) isolates.

Methods: Three hundred forty-two isolates of Enterobacter cloacae were collected from January 2014 to December 2018.

The activity of polymyxin B and tigecycline alone and combination with other antibiotics against carbapenem-resistant complex isolates, including high-risk clones.

Background: The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has become a significant problem for global public health. Currently, treatments program is minimal. This study aimed to evaluate the molecular mechanisms of carbapenem-resistant complex isolates (CREC) infections.

Molecular characterization of metallo-β-lactamase- producing carbapenem-resistant Enterobacter cloacae complex isolated in Heilongjiang Province of China.

Background: Enterobacter cloacae complex (ECC) is one of the most common extended-spectrum β-lactamase and carbapenemase-producing pathogen that threatens millions of the elderly and vulnerable sick persons. The objective of this study was to perform the molecular characteristics of the carbapenem-resistant E. cloacae complex (CREC) emerged in Heilongjiang Province of China.

Correction to: Outbreak of carbapenem-resistant Acinetobacter baumannii carrying the carbapenemase OXA-23 in ICU of the eastern Heilongjiang Province, China.

After publication of the original article [1], we were notified that an author's name has been incorrectly spelled. Sedzro Divine Mensal should be replaced with Sedzro Divine Mensah.

Outbreak of carbapenem-resistant Acinetobacter baumannii carrying the carbapenemase OXA-23 in ICU of the eastern Heilongjiang Province, China.

Background: To investigate the carbapenem resistance mechanisms and clonal relationship of carbapenem-resistant Acinetobacter baumannii (CRAB) strains isolated in the intensive care unit (ICU) of the First Affiliated Hospital of Jiamusi University, management approaches to ICU clonal CRAB outbreaks were described.

Methods: The sensitivity of the antibiotic was determined using the VITEK-2 automated system. Carbapenemase genes (bla, bla, bla, bla, bla, bla, bla, bla, bla, and bla), AmpC enzyme genes (bla, bla, bla), and ISAba1 were assessed for all collected isolates using polymerase chain reaction (PCR).