Publications by authors named "Kevyn J Clark"
Importance: The phase 3 randomized EMBARK trial evaluated enzalutamide with or without leuprolide in high-risk nonmetastatic hormone-sensitive prostate cancer. Eligibility relied on conventional imaging, which underdetects metastatic disease compared with prostate-specific membrane antigen-positron emission tomography (PSMA-PET).
Objective: To describe the staging information obtained by PSMA-PET/computed tomography (PSMA-PET/CT) in a patient cohort eligible for the EMBARK trial.
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Article Synopsis
- - The study assessed the impact of prostate-specific membrane antigen positron emission tomography (PSMA-PET) on the biochemical recurrence-free survival (BRFS) rate in patients undergoing salvage radiotherapy (SRT) after radical prostatectomy for prostate cancer.
- - A total of 193 patients were randomized into two groups: one receiving SRT based on standard imaging (control group) and the other receiving PSMA-PET before SRT planning (investigational group), with 178 patient treatment plans analyzed.
- - Results revealed that PSMA-PET significantly influenced treatment plans, with major management changes occurring in 45% of patients in the PSMA-PET arm compared to 22% in the control arm, highlighting its potential to