Publications by authors named "Kevin Z Qi"
J Am Soc Nephrol
March 2022
Article Synopsis
- Endothelial cell injury plays a significant role in acute kidney injury (AKI) during the COVID-19 pandemic and is linked to the integrin 5 (ITGA5) and the Tie2 signaling pathway.
- Various experiments showed that miR-218-5p, a microRNA, is upregulated in kidney-derived endothelial progenitor cells (EPCs) following ischemia and leads to decreased ITGA5 protein expression, adversely affecting signaling pathways involved in cell migration.
- Using a genetic knockout model, it was found that the absence of miR-218-5p specifically in angioblasts resulted in severe vascular issues, highlighting miR-218-5p's crucial role in regulating EPC movement and its potential impact
