PRAME immunohistochemistry is useful in differentiating oral melanomas from nevi and melanotic macules.

Background: Oral melanocytic neoplasms pose a diagnostic challenge to pathologists owing to their rarity relative to those in the skin. The utility of PRAME in distinguishing nevi from melanomas has been established in the skin, but limited information exists regarding its usefulness in the oral cavity.

Methods: Thirty-five previously diagnosed pigmented oral lesions were retrospectively evaluated with PRAME.