Publications by authors named "Kevin Y Tse"
Patient-Reported Burden of Indolent Systemic Mastocytosis in a Managed Care Organization.
J Allergy Clin Immunol Pract
October 2024
Article Synopsis
- Indolent systemic mastocytosis (ISM) is the most common form of systemic mastocytosis, and its diagnostic challenges and impact on patients' lives need more examination.
- A survey of 40 adults with ISM revealed a lengthy diagnosis process, averaging over two years, with many patients experiencing severe symptoms that negatively affected their quality of life and work ability.
- The study found a strong correlation between symptom severity and physical/mental health scores, highlighting that those with moderate to severe symptoms suffered significantly more from skin and gastrointestinal issues compared to those with mild symptoms.
MASTering systemic mastocytosis: Lessons learned from a large patient cohort.
J Allergy Clin Immunol Glob
November 2024
Article Synopsis
- Systemic mastocytosis (SM) is a rare disease affecting about 32,000 people in the U.S., often misdiagnosed due to vague symptoms and the necessity for invasive tests.
- A study of 116 patients revealed that the majority had indolent SM, with a significant average delay of 58.3 months for diagnosis, and some patients progressed to more advanced forms.
- The findings emphasize the need for better awareness and understanding of SM to improve diagnosis and treatment, suggesting that further studies are necessary to establish effective follow-up care for patients.
The Utility of the Reflux Symptom Index for Diagnosis of Laryngopharyngeal Reflux in an Allergy Patient Population.
J Allergy Clin Immunol Pract
October 2019
Background: Laryngopharyngeal reflux (LPR) is associated with asthma, vocal cord dysfunction, cough, postnasal drainage, and throat irritation. The Reflux Symptom Index (RSI) is a clinical tool to predict the presence of LPR, but a threshold RSI score has never been validated for the diagnosis of LPR in an allergic patient population.
Objective: To identify the optimal threshold RSI score predictive of LPR in an allergy clinic population.
Anabolic androgen use in the management of hereditary angioedema: Not so cheap after all.
Ann Allergy Asthma Immunol
April 2017
Background: Hereditary angioedema due to C1 inhibitor deficiency (HAE) is a rare, life-threatening disease that imposes a significant burden on affected patients. 17α-alkylated androgens (anabolic androgens) decrease attack frequency and severity but carry the risk of potentially serious dose-related adverse effects. Despite the emergence of targeted therapies for HAE, continued anabolic androgen use has been driven in part by their low cost.
View Article and Find Full Text PDFOn the basis of mouse I-A-binding motifs, two sequences of the murine apolipoprotein B-100 (mApoB-100), mApoB-100 (designated P3) and mApoB-100 (designated P6), were found to be immunogenic. In this report, we show that P6 is also atherogenic. Immunization of mice fed a high-fat diet (HFD) with P6 resulted in enhanced development of aortic atheroma as compared to control mice immunized with an irrelevant peptide MOG or with complete Freund's adjuvant alone.
View Article and Find Full Text PDFEosinophilic gastroenteritis due to egg allergy presenting as acute pancreatitis.
Allergy Rhinol (Providence)
January 2015
Article Synopsis
- - A 25-year-old woman was diagnosed with an egg allergy and exhibited eosinophilia in her blood and duodenum, indicating a potential case of eosinophilic gastroenteritis (EG).
- - The severity of her EG likely contributed to acute pancreatitis, a serious inflammation of the pancreas.
- - After she stopped consuming all egg products, her symptoms fully resolved, making this the first documented instance of EG causing pancreatitis related to egg ingestion.
Article Synopsis
- Bone mineral density (BMD) measures the mineral content in bones, and DEXA scans are used to diagnose low bone density diseases.
- The study examines the genetic influence on BMD in monozygotic twins, measuring heritability across 13 body regions.
- Results indicate that BMD heritability varies by gender and body region, with the head showing the highest heritability (>95%) and distinct trends for hip and pelvic BMD between males and females.
Specification of mammalian T lymphocytes involves prolonged developmental plasticity even after lineage-specific gene expression begins. Expression of transcription factor PU.1 may maintain some myeloid-like developmental alternatives until commitment.
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