Publications by authors named "Kevin Y Shim"
Article Synopsis
- Events of status epilepticus (SE) can lead to the development of temporal lobe epilepsy (TLE), which often results in cognitive impairments and memory defects due to hippocampal injury.
- A study suggests that the proliferation of reactive microglia after SE plays a role in these cognitive deficits, and treatment with the CSF1R inhibitor PLX3397 could potentially alleviate these issues.
- In their experiments, both control and SE rats receiving PLX3397 showed reduced microglial numbers and improved memory function; however, SE rats still displayed significant memory deficits compared to controls, indicating that while microglial targeting may help, it doesn't fully resolve the cognitive impairments associated with SE.
