Publications by authors named "Kevin Winardi"
Background: Optimal heart failure (HF) pharmacotherapy (guideline-directed medical therapy and diuretics) in older people with frailty is uncertain due to limited evidence.
Aims: To evaluate utilisation of HF pharmacotherapy and prevalence of polypharmacy, adverse drug events (ADEs), falls, delirium, renal impairment and duration of hospitalisation in older inpatients, according to frailty.
Methods: A retrospective cross-sectional study of the TO HOME cohort of 2000 inpatients ≥75 years admitted for ≥48 h to rehabilitation, geriatric or general medicine from 1 July 2016 to 30 June 2017 across six hospitals in Sydney, Australia.
Article Synopsis
- Polypharmacy, defined as the use of five or more medications, is common in older adults and can lead to serious health issues like cognitive decline, falls, and higher mortality rates.
- A study was conducted on male mice to analyze the effects of both polypharmacy and the strategy of deprescribing (gradually reducing medications) to see how it impacts liver function and related proteins.
- The results showed that polypharmacy caused significant changes in liver protein expression related to immunity and metabolism, while deprescribing had both reversing effects and introduced new changes that could impact geriatric health outcomes.