Publications by authors named "Kevin Timothy Fridianto"
A thermally stable, fluorous sulfur-containing boronic acid catalyst has been developed and was shown to efficiently promote dehydrative condensation between carboxylic acids and amines under environmentally friendly conditions. The methodology can be applied to aliphatic, aromatic and heteroaromatic acids as well as primary and secondary amines. -Boc protected amino acids were also successfully coupled in good yields with very little racemization.
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- Mycobacterial bioenergetics is a promising target for new anti-tuberculosis drugs due to its importance in energy generation and bacteria survival.
- The study involved modifying naphthoquinoneimidazoles by adding a trialkylphosphonium cation to enhance their antimycobacterial activity through changes in the structure.
- The most effective compound showed a strong selectivity index and bactericidal action by causing rapid depolarization of bacterial membranes, leading to decreased ATP levels and maintaining excellent antibacterial properties.
Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury (IRI) but the mechanisms are unknown. Here, we investigate the role of the mitochondrial NAD-dependent deacetylase, Sirtuin-3 (SIRT3), which has been shown to influence fatty acid oxidation and cardiac outcomes, as a potential mediator of this effect. Fasting was shown to shift metabolism from glucose towards fatty acid oxidation.
View Article and Find Full Text PDFAmong community cohorts, associations between clinical and metabolite factors and complex left atrial (LA) phasic function assessed by cardiac magnetic resonance (CMR) feature tracking (FT) are unknown. Longitudinal LA strain comprising reservoir strain (εs), conduit strain (εe) and booster strain (εa) and their corresponding peak strain rates (SRs, SRe, SRa) were measured using CMR FT. Targeted mass spectrometry measured 83 circulating metabolites in serum.
View Article and Find Full Text PDFBackground: Increasing arterial stiffness is an important contributor to declining cardiovascular health in ageing. Changes in whole-body fuel metabolism could be related to alterations in arterial stiffness in ageing adults.
Methods: Targeted high-performance liquid and gas chromatography mass spectrometry were used to measure 84 circulating metabolites in a group of community elderly adults ( n = 141, 58% men; mean age = 70.