Using biomarkers in wastewater to monitor community drug use: a conceptual approach for dealing with new psychoactive substances.

Data obtained from the analysis of wastewater from large-scale sewage treatment plants has been successfully applied to study trends in the use of classical illicit drugs such as cocaine, but the dynamic nature of the new psychoactive substances (NPS) market presents a unique set of challenges to epidemiologists. In an attempt to overcome some of the challenges, this paper presents a framework whereby a collection of tools and alternative data-sources can be used to support the design and implementation of wastewater-based studies on NPS use. Within this framework the most likely and most suitable biomarkers for a given NPS are predicted via in-silico metabolism, biotransformation and sorption models.

Effects of prenatal methamphetamine exposure: a review of cognitive and neuroimaging studies.

Prenatal methamphetamine exposure (PME) is a significant problem in several parts of the world and poses important health risks for the developing fetus. Research on the short- and long-term outcomes of PME is scarce, however. Here, we summarize present knowledge on the cognitive and behavioral outcomes of PME, based on a review of the neuroimaging, neuropsychology, and neuroscience literature published in the past 15 years.

Management of postoperative atrial fibrillation and subsequent outcomes in contemporary patients undergoing cardiac surgery: insights from the Society of Thoracic Surgeons CAPS-Care Atrial Fibrillation Registry.

Background: Postoperative atrial fibrillation (POAF) is a well-recognized complication of cardiac surgery; however, its management remains a challenge, and the implementation and outcomes of various strategies in clinical practice remain unclear.

Hypothesis: We hypothesize that treatment for POAF is variable, and that it is associated with particular morbidity and mortality following cardiac surgery.

Methods: We compared patient characteristics, operative procedures, postoperative management, and outcomes between patients with and without POAF following coronary artery bypass grafting (CABG) in the Society of Thoracic Surgeons multicenter Contemporary Analysis of Perioperative Cardiovascular Surgical Care (CAPS-Care) registry (2004-2005).

Demographic profile of severe traumatic brain injury admissions to Red Cross War Memorial Children's Hospital, 2006 - 2011.

Background: Paediatric traumatic brain injury (PTBI) is a major public health problem. However, recent epidemiological data for PTBI in South Africa (SA) are lacking.

Objectives: To establish a demographic profile of severe PTBI admissions to the Red Cross War Memorial Children's Hospital (RCWMCH) over a 5-year period, by investigating trends in annual admissions, age, sex, language, time and day of injury, and aetiology.

Rates of cardiopulmonary resuscitation training in the United States.

Importance: Prompt bystander cardiopulmonary resuscitation (CPR) improves the likelihood of surviving an out-of-hospital cardiac arrest. Large regional variations in survival after an out-of-hospital cardiac arrest have been noted.

Objectives: To determine whether regional variations in county-level rates of CPR training exist across the United States and the factors associated with low rates in US counties.

Check it, change it: a community-based intervention to improve blood pressure control.

Background: Despite the widespread availability of effective and affordable therapies, hypertension remains this country's most significant modifiable cardiovascular risk factor. Approximately 30% to 50% of individuals with hypertension currently fail to reach guideline-recommended target blood pressure (BP) goals. Although multiple interventions have been proposed to affect better hypertension control, the integration of multiple elements in a community-based program has not been evaluated to date.

The effect of an even-pacing strategy on exercise tolerance in well-trained cyclists.

Purpose: Previous research has suggested that the optimal pacing strategy for self-paced exercise lasting >4 min is a uniform distribution of work, but this posit is not well established for prolonged endurance events. This study examined the utility of even pacing during 20 km cycling time trials (TTs).

Methods: Fifteen well-trained male cyclists ([Formula: see text]O2max = 4.

Racial differences in the prevalence and outcomes of atrial fibrillation among patients hospitalized with heart failure.

Background: The intersection of heart failure (HF) and atrial fibrillation (AF) is common, but the burden of AF among black patients with HF is poorly characterized. We sought to determine the prevalence of AF, characteristics, in-hospital outcomes, and warfarin use associated with AF in patients hospitalized with HF as a function of race.

Methods And Results: We analyzed data on 135 494 hospitalizations from January 2006 through January 2012 at 276 hospitals participating in the American Heart Association's Get With The Guidelines HF Program.

Should silicone prostheses be considered for specimen banking? A pilot study into their use for human biomonitoring.

Persistent organic pollutant (POP) biomonitoring in humans is challenging and generally carried out using blood, breast milk or adipose tissue, with concentrations normalised to the lipid content of the sample matrix. The goal of this cross-sectional pilot study was to evaluate the validity and feasibility of explanted silicone prostheses as a matrix for persistent organic pollutant biomonitoring in humans. We postulate that pollutant concentrations in silicone prostheses inserted in the body will equilibrate with that in the body over time and provide a measure of the overall body burden.

Educational videos to reduce racial disparities in ICD therapy via innovative designs (VIVID): a randomized clinical trial.

Background: Black individuals eligible for an implantable cardioverter/defibrillator (ICD) are considerably less likely than white individuals to receive one. This disparity may, in part, be explained by racial differences in patient preferences. We hypothesized that a targeted patient-centered educational video could improve knowledge of sudden cardiac arrest (SCA) and ICDs and reduce racial differences in ICD preferences.

Cradling bias is absent in children with autism spectrum disorders.

Objective: This study investigated relations among empathy and cradling bias in children diagnosed with autism spectrum disorders (ASDs).

Method: Twenty children with ASDs and 20 typically developing (TD) children, aged 5-15 years old, cradled a doll as if it were an infant s/he was putting to sleep on three separate occasions. We recorded side preference on each occasion.

Effects of simulated weathering on the toxicity of selected crude oils and their components to sea urchin embryos.

Artificial weathering of Angolan crude and a Heavy Fuel Oil (HFO) was performed by evaporation and photooxidation. The aliphatic, aromatic, polar and asphaltene fractions of the fresh and weathered oils were isolated. The toxicity of the water accommodated fraction or an oil/fraction dissolved in DMSO was assessed using the sea urchin embryo test.

Performance measures to promote quality improvement in sudden cardiac arrest prevention and treatment.

Sudden cardiac arrest (SCA) is one of the most impactful public health problems in the United States. Despite the progress made in reducing the number of cardiac deaths, the incidence of sudden cardiac death remains high. Studies of life-saving interventions for prevention and treatment of SCA, like β-blockers, aldosterone antagonists, implantable cardioverter defibrillator therapy, automated external defibrillators, and cardiopulmonary resuscitation, have brought to light substantial underutilization, variations in care, and disparities.

Assessment of the quality of existing patient educational tools focused on sudden cardiac arrest: a systematic evaluation by the Sudden Cardiac Arrest Thought Leadership Alliance.

Background: Conveying contemporary treatment options for those at risk of sudden cardiac arrest (SCA) is challenging. The purpose of the present research was to evaluate the quality and usability of available patient educational tools relevant to SCA and its treatment options, such as implantable cardioverter defibrillators (ICDs). We hypothesized that this review would identify gaps in areas of information for the enhancement of patient education and decision-making materials.

Passive sampling for target and nontarget analyses of moderately polar and nonpolar substances in water.

The applicability of silicone rubber and low-density polyethylene (LDPE) as passive sampling materials for target and nontarget analyses of moderately polar and nonpolar substances was assessed through a field deployment of samplers along a small, polluted stream in Oslo, Norway. Silicone and LDPE samplers of identical surface area (but different volumes) were deployed at 6 sites in the River Alna for 49 d. Quantitative target analysis by gas chromatography-mass spectrometry (quadrupole, single-ion monitoring mode) demonstrated that masses of polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and organochlorine compounds absorbed in the 2 polymeric materials were consistent with the current understanding of the control and mode of accumulation in these sampler materials.

The occurrence of second generation anticoagulant rodenticides in non-target raptor species in Norway.

Second generation anticoagulant rodenticides (SGARs) are commonly used for rodent pest control in Norway resulting in the potential exposure of non-target raptor species. In this study the occurrence of flocoumafen, difethialone, difenacoum, bromadiolone and brodifacoum was determined in the livers of five species of raptors found dead in Norway between 2009 and 2011. The SGARs brodifacoum, bromadiolone, difenacoum and flocoumafen were detected in golden eagle (Aquila chrysaetos) and eagle owl (Bubo bubo) livers at a total SGAR concentration of between 11 and 255 ng/g in approximately 70% of the golden eagles and 50% of the eagle owls examined in this study.

Analysis of new classes of recreational drugs in sewage: synthetic cannabinoids and amphetamine-like substances.

The analysis of sewage for the residues of commonly used illicit drugs has successfully been applied as a suitable approach for estimating community illicit drug use. The drug market is increasingly dynamic with new substances continually being marketed for recreational purposes. In this study, ultra-high pressure liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) was used to simultaneously and quantitatively detect the exogenous biomarkers of new classes of recreational drugs in sewage collected from three different Norwegian cities (Oslo, Bergen, Hamar).

Biotransformation kinetics and sorption of cocaine and its metabolites and the factors influencing their estimation in wastewater.

The quantitative analysis of human urinary metabolites as biomarkers in wastewater streams has been used to estimate the rates of illicit drug use in the wider community. The primary underlying assumption in such studies is that a sample of wastewater is equivalent to a cumulative sample of urine. Drug metabolism in humans is predominantly enzymatically mediated, but these processes are not exclusive to the human body, and are found to occur in the environment and the sewer network.

Exploring the utility of the Montreal Cognitive Assessment to detect HIV-associated neurocognitive disorder: the challenge and need for culturally valid screening tests in South Africa.

There is a strong need in South Africa for neuropsychological tests that can help detect HIV-associated neurocognitive disorder (HAND) in the country's 5.6 million people living with HIV. Yet South African neuropsychologists are challenged to do so, as few neuropsychological tests or batteries have been developed or adapted for, and normed on, South Africa's linguistically, culturally, educationally, and economically diverse population.

Evaluation of uncertainties associated with the determination of community drug use through the measurement of sewage drug biomarkers.

The aim of this study was to integrally address the uncertainty associated with all the steps used to estimate community drug consumption through the chemical analysis of sewage biomarkers of illicit drugs. Uncertainty has been evaluated for sampling, chemical analysis, stability of drug biomarkers in sewage, back-calculation of drug use (specific case of cocaine), and estimation of population size in a catchment using data collected from a recent Europe-wide investigation and from the available literature. The quality of sampling protocols and analytical measurements has been evaluated by analyzing standardized questionnaires collected from 19 sewage treatments plants (STPs) and the results of an interlaboratory study (ILS), respectively.

Neuropsychological, functional, and behavioral outcome in South African traumatic brain injury litigants.

Few studies address the extent to which, during the process of litigation, individuals with moderate-to-severe traumatic brain injury might malinger in their performance on neuropsychological assessment batteries. This study explored whether financial settlement influenced neuropsychological test performance and activities of daily living in litigants (N = 31) who were tested and interviewed both during litigation and 1 year or more after case settlement. Results showed that neuropsychological test scores did not change from assessment during forensic proceedings to assessment after settlement.

Estimation of cocaine consumption in the community: a critical comparison of the results from three complimentary techniques.

Objectives: A range of approaches are now available to estimate the level of drug use in the community so it is desirable to critically compare results from the differing techniques. This paper presents a comparison of the results from three methods for estimating the level of cocaine use in the general population.

Design: The comparison applies to; a set of regional-scale sample survey questionnaires, a representative sample survey on drug use among drivers and an analysis of the quantity of cocaine-related metabolites in sewage.

Effects of salinity on the toxicity of ionic silver and Ag-PVP nanoparticles to Tisbe battagliai and Ceramium tenuicorne.

The toxic effects of polyvinylpyrrolidone (PVP) coated silver nanoparticles (Ag-NP(PVP)) and ionic Ag, to Tisbe battagliai (Tb) and Ceramium tenuicorne (Ct) were investigated and the usefulness of standardised marine guidelines for ENP risk assessment were assessed. The toxicity of Ag-NP(PVP) [CtEC(50)=26.6μg/L, TbEC(50)=7.

Observer effects on the rating of perceived exertion and affect during exercise in recreationally active males.

This study examined the effect of introducing either a male or female observer on the ratings of perceived exertion (RPE) and affect of male runners during a moderate intensity running task. 10 moderately active men completed three 20-min. moderate intensity running trials at 60% of their peak treadmill running speed.