Supportive care of right ventricular failure due to fat embolism syndrome.

Pulmonary fat embolism is a common phenomenon in cases of traumatic long bone fractures, with only a minority developing the more catastrophic Fat Embolism Syndrome (FES). Diagnosis is clinical and requires a high index of suspicion. Treatment remains under-investigated, with common interventions having low quality level-of-evidence and no mortality benefit.

Impact of intraosseous versus intravenous resuscitation during in-hospital cardiac arrest: A retrospective study.

Aim: To compare outcomes between Intraosseous (IO) and peripheral intravenous (PIV) injection during in-hospital cardiac arrest (IHCA) and examine its utility in individuals with obesity.

Methods: We performed a retrospective cohort analysis of adult, atraumatic IHCA at a single tertiary care center. Subjects were classified as either IO or PIV resuscitation.

Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency.

Human disorders of the post-squalene cholesterol biosynthesis pathway frequently result in skeletal abnormalities, yet our understanding of the mechanisms involved is limited. In a forward-genetic approach, we have found that a late-onset skeletal mutant, named , is the result of a -acting regulatory mutation leading to loss of () expression within pre-hypertrophic chondrocytes. Generated knockdown mutation resulted in lethality at larval stage.

A 190 base pair, TGF-β responsive tooth and fin enhancer is required for stickleback Bmp6 expression.

The ligands of the Bone Morphogenetic Protein (BMP) family of developmental signaling molecules are often under the control of complex cis-regulatory modules and play diverse roles in vertebrate development and evolution. Here, we investigated the cis-regulatory control of stickleback Bmp6. We identified a 190bp enhancer ~2.