Publications by authors named "Kevin T Mueller"
Disease-modifying antirheumatic drugs and risk of incident interstitial lung disease among patients with rheumatoid arthritis: A systematic review and meta-analysis.
Semin Arthritis Rheum
December 2024
Article Synopsis
- The study aimed to explore if disease-modifying antirheumatic drugs (DMARDs) increase the risk of developing interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) through a systematic review and meta-analysis of existing research.* -
- From 3,612 studies, 40 were included, covering 486,465 RA patients and 3,928 cases of ILD; overall, no significant link was found between specific DMARDs and ILD in analyzed randomized controlled trials.* -
- However, observational studies indicated that methotrexate (MTX) may reduce the odds of developing ILD, while a large trial comparing tofacitinib with another treatment showed no significant relationship
Purpose Of Review: The goal of this review paper is to summarize the main research and findings regarding air pollution and its association with the risk and progression of rheumatoid arthritis (RA).
Recent Findings: The most studied components of air pollution included particulate matter of ≤ 2.5 microns in diameter (PM), PM, carbon monoxide (CO), nitrogen dioxide (NO), nitric oxide (NOx), sulfur dioxide (SO), and ozone (O).
We aimed to determine the prevalence and outcomes for forced vital capacity percent predicted (FVCpp) decline among patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). We identified patients with RA-ILD in the Mass General Brigham Healthcare system. RA-ILD diagnosis was determined by review of high-resolution computed tomography (HRCT) imaging by up to three thoracic radiologists.
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