Publications by authors named "Kevin T Douglas"
Neuropharmacology
March 2022
Article Synopsis
- Genetic differences in cerebellar sensitivity to alcohol influence alcohol consumption behaviors in rodents, which may reflect risks for alcohol use disorders in humans.
- Low alcohol-consuming rodent genotypes, like B6N mice, show enhanced GABAR currents in response to alcohol, while high alcohol-consuming genotypes, like B6J mice, show suppressed currents, linked to nNOS expression.
- B6N mice consume less alcohol than B6J mice, not due to taste differences, but because of higher nNOS levels leading to increased GABAR activity, illustrating how genetic variation can affect alcohol intake behaviors.
