Publications by authors named "Kevin Sw Tan"
Article Synopsis
- The large intestine hosts microorganisms that influence host health, with the balance between different types of CD4 T cells playing a crucial role.
- Infection with the protist Blastocystis ST7 in mice triggers ulcerative colitis-like symptoms by lowering anti-inflammatory Treg cells and increasing pro-inflammatory Th17 cells through the action of a tryptophan metabolite called indole-3-acetaldehyde (I3AA).
- I3AA affects Treg cell function and development, enhancing CD4 T cell responses, which highlights the complex interaction between gut microbiota, metabolites, and immune system regulation, especially concerning gut inflammation.
Hypnozoites are the liver stage non-dividing form of the malaria parasite that are responsible for relapse and acts as a natural reservoir for human malaria Plasmodium vivax and P. ovale as well as a phylogenetically related simian malaria P. cynomolgi.
View Article and Find Full Text PDFThe absolute configuration (via degradation and Marfey's derivatization studies) and the total synthesis of a novel antimalarial lipid-peptide isolated from Streptomyces sp. (IC(50) = 0.8 μM, Plasmodium falciparum 3D7) is disclosed.
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