Publications by authors named "Kevin Sicking"
Article Synopsis
- Parkinson's disease (PD) affects a small percentage of patients with a monogenic form linked to mutations in the alpha-synuclein (aSyn) gene, specifically missense variants that can cause familial PD.
- A case study highlighted a patient with a novel heterozygous aSyn mutation (G14R) showing complex neurodegenerative symptoms and neuropathological findings typical of frontotemporal lobar degeneration.
- Research on the G14R mutation indicated structural changes in aSyn, leading to increased inclusion formation and altered fibrillar morphologies, suggesting mechanisms for the observed disease characteristics.
Article Synopsis
- * The cryogenic electron microscopy (cryo-EM) analysis of heart-derived AL amyloid (AL59) revealed a unique double-layered structure with a u-shaped core that challenges previous assumptions about the building blocks of amyloid fibrils.
- * Additionally, the study found that collagen VI (COLVI) wraps around the amyloid fibrils, forming a protective helical superstructure, indicating a possible new mechanism for the stability and persistence of amyloid deposits in the body.
Forisomes are large mechanoprotein complexes found solely in legumes such as Medicago truncatula. They comprise several "sieve element occlusion by forisome" (SEO-F) subunits, with MtSEO-F1 as the major structure-forming component. SEO-F proteins possess three conserved domains -an N-terminal domain (SEO-NTD), a potential thioredoxin fold, and a C-terminal domain (SEO-CTD)- but structural and biochemical data are scarce and little is known about the contribution of these domains to forisome assembly.
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