Publications by authors named "Kevin S Hou"
Article Synopsis
- The study investigates the role of Notch4 signaling in arteriovenous malformations (AVMs) using a mouse model with active Notch4 in endothelial cells.
- Notch4 activation leads to decreased vascular tone, indicated by reduced pressure response in brain arteries and can be corrected with a nitric oxide synthase (NOS) inhibitor.
- The findings suggest that endothelial NOS (eNOS) enhances hydrogen peroxide production, which contributes to the initiation and progression of AVMs through decreased vascular tone.
