A Rare Presentation of Metastatic Renal Cell Carcinoma Masquerading as Vitritis: A Case Report and Review of Literature.

We report a case of a 74-year-old gentleman who presented with floaters and decreased vision in the right eye after cataract surgery. His past medical history was significant for metastatic renal cell carcinoma (mRCC) to bone, lung and abdomen which was presumed stable for the last two years while on the tyrosine kinase inhibitor (TKI), pazopanib. Clinical examination revealed significant vitritis with a distinctive clumping of cells on the pre-retinal surface and posterior hyaloid face.

Incidence, Management, and Surgical Outcomes of Macular Splitting Rhegmatogenous Retinal Detachment.

Background And Objective: Limited knowledge exists regarding macular splitting retinal detachment (RD). The purpose of this study is to investigate clinical features and outcomes of macular splitting RD.

Patients And Methods: This was a retrospective case series performed at a single practice.

Pars Plana Vitrectomy Outcomes for Rhegmatogenous Retinal Detachment Qualifying for Pneumatic Retinopexy.

Purpose: To investigate real-world outcomes of pars plana vitrectomy (PPV) for eyes with primary rhegmatogenous retinal detachments (RRD) eligible for pneumatic retinopexy (PnR).

Methods: This was a single center retrospective case series looking at consecutive patients with primary RRDs. A database was created on all patients with a primary RRD from 2010 to 2018 based on billing code 67108.

Computing exact coherent states in channels starting from the laminar profile: A resolvent-based approach.

We present an iterative method to compute traveling wave exact coherent states (ECS) in Couette and Poiseuille flows starting from an initial laminar profile. The approach utilizes the resolvent operator for a two-dimensional, three-component streamwise-averaged mean and exploits the underlying physics of the self-sustaining process. A singular value decomposition of the resolvent operator is used to obtain the mode shape for a single streamwise-varying Fourier mode.

Increased Reoperation Rate in Surgical Treatment of Rhegmatogenous Retinal Detachment with Coexistent Macular Hole.

Purpose: To examine the surgical outcomes in patients with coexistent macular hole (MH) and rhegmatogenous retinal detachment (RRD).

Design: Retrospective case series.

Participants: All patients who underwent surgical repair of concomitant MH and retinal detachment (MHRD) between January 2014 and December 2016 in our facility were examined.

Topiramate-induced macular neurosensory retinal detachment.

Purpose: To present a previously unreported retinal side-effect from topiramate use in two cases.

Observations: Macular neurosensory retinal detachments were seen in two patients shortly after beginning oral topiramate. The macular detachments resolved shortly after discontinuing this medication.

Dual Intravitreal Injections With Foscarnet and Ganciclovir for Ganciclovir-Resistant Recurrent Cytomegalovirus Retinitis in a Congenitally Infected Infant.

Resistant strains of cytomegalovirus can be difficult to treat in cases of congenital cytomegalovirus retinitis. The authors describe a case of recurrent bilateral congenital cytomegalovirus retinitis in an immunocompetent newborn with ganciclovir resistance successfully treated uniquely with dual therapy of intravenous ganciclovir and foscarnet and dual intravitreal injections with ganciclovir and foscarnet. [J Pediatr Ophthalmol Strabismus.

The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development.

Local control of cell signaling activity and integration of inputs from multiple signaling pathways are central for normal development but the underlying mechanisms remain poorly understood. Here we show that Dkk2, encoding an antagonist of canonical Wnt signaling, is an essential downstream target of the PITX2 homeodomain transcription factor in neural crest during eye development. Canonical Wnt signaling is ectopically activated in central ocular surface ectoderm and underlying mesenchyme in Pitx2- and Dkk2-deficient mice.

Genetic markers and biomarkers for age-related macular degeneration.

Age-related macular degeneration (AMD) is the leading cause of visual impairment and blindness in the USA. Although the treatment of AMD has evolved to include laser photocoagulation, photodynamic therapy, surgical macular translocation and antiangiogenesis agents, treatment options for advanced AMD are limited. Furthermore, the dry form of AMD, albeit less devastating than the wet form, has even fewer viable treatment options.

Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration.

Purpose: Senescent Ccl2(-/-) mice are reported to develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are also found to be associated with AMD. The authors generated Ccl2(-/-)/Cx3cr1(-/-) mice to establish a more characteristic and reproducible AMD model.