Publications by authors named "Kevin Pouxvielh"
Article Synopsis
- NK cells often lose their function during tumor development, but the reasons for this are not fully understood.
- In mouse lymphoma models, the activation of NK cells led to changes resembling T cell exhaustion, including the expression of immune checkpoint proteins, but dysfunction occurred only in the activated NK cell group.
- Importantly, NK cell dysfunction can be reversed by stopping the stimulation and is positively influenced by interleukin-15, indicating that the dysfunction is a dynamic and reversible process not directly linked to immune checkpoint protein expression.
Article Synopsis
- Scientists are trying to understand how asbestos causes the body to attack itself, which is called autoimmunity.
- They found that a type of asbestos called pristine amosite (pAmo) caused more lung damage and immune issues in mice compared to milled amosite (mAmo).
- The study showed that pAmo can make certain cells in the immune system act differently, leading to problems like lung fibrosis and producing harmful antibodies.
Article Synopsis
- Autosomal recessive PRKCD deficiency is linked to systemic lupus erythematosus, but its specific mechanisms are not well understood.
- Researchers created a mouse model with the Prkcd G510S mutation to study the disease, which mimics human symptoms and shows a shortened lifespan.
- The study found that this mutation affects B cell activation through the PI3K/mTOR pathway, leading to autoimmune symptoms that improve with rapamycin treatment, highlighting the pathway's role in PRKCD-related autoimmunity and reduced NK cell levels contributing to viral infection susceptibility.
Article Synopsis
- NK cell receptors help NK cells identify and attack tumor cells, with diverse combinations of receptors present on different NK cell subsets, leading to varied responses.
- Research using a mouse model examined the responses of 444 NK cell subsets with different receptor combinations against various tumor cell lines, finding similar reactivity patterns across tumor types.
- Specific receptors like CD27 and NKG2A were linked to cytotoxic activity, while others influenced IFN-γ production, suggesting that receptor interactions and factors like IL-15 are crucial for optimizing NK cell therapy strategies.
EOMES and T-BET are related T-box transcription factors that control natural killer (NK) cell development. Here we demonstrate that EOMES and T-BET regulate largely distinct gene sets during this process. EOMES is dominantly expressed in immature NK cells and drives early lineage specification by inducing hallmark receptors and functions.
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