Publications by authors named "Kevin Peasley"
Acute kidney injury (AKI) is an extremely common medical affliction affecting both adult and pediatric patients resulting from hypoxic, nephrotoxic, and septic insults affecting approximately 20% of all hospital patients and up to 50% of patients in the intensive care unit. There are currently no therapeutics for patients who suffer AKI. Much recent work has focused on designing and implementing therapeutics for AKI.
View Article and Find Full Text PDFMedium-chain triglycerides (MCT), containing C-C fatty acids, are used to treat several pediatric disorders and are widely consumed as a nutritional supplement. Here, we investigated the role of the sirtuin deacylase Sirt5 in MCT metabolism by feeding Sirt5 knockout mice (Sirt5KO) high-fat diets containing either C/C fatty acids or coconut oil, which is rich in C, for five weeks. Coconut oil, but not C/C feeding, induced periportal macrovesicular steatosis in Sirt5KO mice.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of Sirtuin 5 (Sirt5) in regulating energy metabolism in kidney cells during acute kidney injury (AKI), focusing on fatty acid oxidation.
- Sirt5-deficient mice showed increased fatty acid oxidation in peroxisomes and better kidney function after AKI compared to controls, suggesting a protective role against tissue damage.
- These findings highlight the potential for targeting Sirt5 to develop new therapies for AKI by manipulating cellular energy pathways.