Publications by authors named "Kevin Mouilleseaux"
Article Synopsis
- Oxidized phospholipids, like OxPAPC, contribute to inflammation in endothelial cells by inducing chemokines like IL-8 and causing cholesterol depletion, leading to altered cellular signaling.
- Cholesterol depletion activates the sterol regulatory element-binding protein (SREBP), which enhances the production of IL-8 by binding to its promoter and is linked to changes in cholesterol levels.
- The study implies that the relationship between cholesterol levels and SREBP activation may play a significant role in the inflammation associated with atherosclerosis.
