Publications by authors named "Kevin M Vogeli"
The vertebrate limb bud arises from lateral plate mesoderm and its overlying ectoderm. Despite progress regarding the genetic requirements for limb development, morphogenetic mechanisms that generate early outgrowth remain relatively undefined. We show by live imaging and lineage tracing in different vertebrate models that the lateral plate contributes mesoderm to the early limb bud through directional cell movement.
View Article and Find Full Text PDFRecent studies have begun to elucidate how the endothelial lineage is specified from the nascent mesoderm. However, the molecular mechanisms which regulate this process remain largely unknown. We hypothesized that Notch signaling might play an important role in specifying endothelial progenitors from the mesoderm, given that this pathway acts as a bipotential cell-fate switch on equipotent progenitor populations in other settings.
View Article and Find Full Text PDFArticle Synopsis
- The concept of a common progenitor, called the haemangioblast, for both haematopoietic and endothelial cells is based on their close developmental proximity in embryos.
- Studies have shown that single progenitor cells can produce both cell types in laboratory settings, although in vivo evidence was still needed.
- Research using fate maps in zebrafish demonstrates that some individual cells can indeed differentiate into both haematopoietic and endothelial cells, confirming the existence of bipotential progenitors and highlighting unique characteristics of the haemangioblast population.