Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19.

Herein is described the development of a large-scale manufacturing process for molnupiravir, an orally dosed antiviral that was recently demonstrated to be efficacious for the treatment of patients with COVID-19. The yield, robustness, and efficiency of each of the five steps were improved, ultimately culminating in a 1.6-fold improvement in overall yield and a dramatic increase in the overall throughput compared to the baseline process.

Effect of adsorbed polyelectrolytes on nanoscale zero valent iron particle attachment to soil surface models.

Polyelectrolyte coatings significantly increase the mobility of nanoscale zerovalent iron (NZVI) in saturated porous media. The effect can be attributed to improved colloidal stability of NZVI suspensions, decreased adhesion to soil surfaces, or a combination of the two effects. This research explicitly examines how coatings control NZVI adhesion to model soil surfaces.