Publications by authors named "Kevin Lalanne"
DNA is the major target of radiation therapy of malignant tumors. Ionizing radiation (IR) induces a variety of DNA lesions, including chemically modified bases and strand breaks. The use of proton beam therapy for cancer treatment is ramping up, as it is expected to reduce normal tissue damage.
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- About 50% of cancer patients need radiotherapy, and while proton therapy offers improved precision for brain tumors, it still causes structural and functional changes in the brain.
- A study using nematodes exposed to protons showed that mitochondrial dysfunction occurs, including a loss of mitochondrial membrane potential and the induction of oxidative stress after radiation.
- The findings also revealed an increase in mitochondrial DNA copy number and evidence of autophagy in the irradiated area, suggesting that understanding these molecular pathways could lead to new treatments for radiation-induced damage.
Article Synopsis
- - Current methods to measure maximum forward lean angle, step length, and velocity in clinical settings are complex and expensive, prompting a study to assess the accuracy of five measurement techniques against 3D motion analysis, the gold standard.
- - Four live measurement methods (LabVIEW, load cell, inclinometer, protractor) and one post-processing method (2D video analysis) were tested with twelve healthy participants recovering balance from various lean angles.
- - Results showed that the LabVIEW method was the most accurate but also the most expensive; simpler options like the protractor and video analysis offered sufficient accuracy and could be more practical for clinical use.
Description.: Recently translated and adapted to the French-Canadian context, the program (Lifestyle Redesign) aims to develop meaningful and healthy lifestyle. The influence of this newly adapted program on older French-Canadians was, however, unknown.
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