Dissociation and other trauma symptomatology are linked to imbalance in the competing neurobehavioral decision systems.

Objective: Dissociation is a conscious state characterized by alterations in sensation and perception and is thought to arise from traumatic life experiences. Previous research has demonstrated that individuals with high levels of dissociation show impairments in cognitive-emotional processes. Therefore, using the Competing Neurobehavioral Decisions System (CNDS) theory, we used statistical modeling to examine whether dissociative experience and trauma symptoms are independently predicted by impulsivity, risk-seeking, affective state (i.

Simulated nonlinear genetic and environmental dynamics of complex traits.

Genetic studies of complex traits often show disparities in estimated heritability depending on the method used, whether by genomic associations or twin and family studies. We present a simulation of individual genomes with dynamic environmental conditions to consider how linear and nonlinear effects, gene-by-environment interactions, and gene-by-environment correlations may work together to govern the long-term development of complex traits and affect estimates of heritability from common methods. Our simulation studies demonstrate that the genetic effects estimated by genome wide association studies in unrelated individuals are inadequate to characterize gene-by-environment interaction, while including related individuals in genome-wide complex trait analysis (GCTA) allows gene-by-environment interactions to be recovered in the heritability.

Hierarchical Biometrical Genetic Analysis of Longitudinal Dynamics.

For many phenotypes, individual scores are obtained as the parameter estimates of person-level models fit to intensive repeated measures from physiological sensors or experience sampling studies. Biometrical genetic analysis of such phenotypes is often done in a 2-step sequence: first the phenotypic parameters are estimated for each individual, then classical twin modeling is used to partition their variance. This study demonstrates deficiencies in accuracy and statistical power of the two-step approach to estimate genetic signals and advocates for the use of hierarchical models to overcome both problems.

County-Level Social Distancing and Policy Impact in the United States: A Dynamical Systems Model.

Background: Social distancing and public policy have been crucial for minimizing the spread of SARS-CoV-2 in the United States. Publicly available, county-level time series data on mobility are derived from individual devices with global positioning systems, providing a variety of indices of social distancing behavior per day. Such indices allow a fine-grained approach to modeling public behavior during the pandemic.

Direct estimation of the parameters of a delayed, intermittent activation feedback model of postural sway during quiet standing.

Human postural sway during quiet standing has been characterized as a proportional-integral-derivative controller with intermittent activation. In the model, patterns of sway result from both instantaneous, passive, mechanical resistance and delayed, intermittent resistance signaled by the central nervous system. A Kalman-Filter framework was designed to directly estimate from experimental data the parameters of the model's stochastic delay differential equations with discrete dynamic switching conditions.

A Method of Correcting Estimation Failure in Latent Differential Equations with Comparisons to Kalman Filtering.

Studies have used the latent differential equation (LDE) model to estimate the parameters of damped oscillation in various phenomena, but it has been shown that correct, non-zero parameter estimates are only obtained when the latent series exhibits little or no process noise. Consequently, LDEs are limited to modeling deterministic processes with measurement error rather than those with random behavior in the true latent state. The reasons for these limitations are considered, and a piecewise deterministic approximation (PDA) algorithm is proposed to treat process noise outliers as functional discontinuities and obtain correct estimates of the damping parameter.

Adaptive Equilibrium Regulation: Modeling Individual Dynamics on Multiple Timescales.

Damped Linear Oscillators estimated by 2nd-order Latent Differential Equation have assumed a constant equilibrium and one oscillatory component. Lower-frequency oscillations may come from seasonal background processes, which non-randomly contribute to deviation from equilibrium at each occasion and confound estimation of dynamics over shorter timescales. Boker (2015) proposed a model of individual change on multiple timescales, but implementation, simulation, and applications to data have not been demonstrated.