Publications by authors named "Kevin L'Esperance"
Article Synopsis
- Excess body fat in older age can increase the risk of ovarian cancer, although the connection is not very strong.
- A study in Montreal analyzed body mass index (BMI) data over decades for women 50 and older to understand different life stages' impact on ovarian cancer risk.
- The findings indicate that the accumulation hypothesis best explains the link between BMI and ovarian cancer risk, particularly highlighting the early childbearing years as a potentially sensitive period for increased risk.
The evidence from previous studies of serum 25-hydroxyvitamin D (25(OH)D) and ovarian cancer risk is not conclusive. However, the 25(OH)D levels were generally only measured in late adulthood, which may not capture the etiologically relevant exposure periods. We investigated predicted 25(OH)D over the adult lifetime in relation to ovarian cancer risk in a population-based case-control study conducted from 2011 to 2016 in Montreal, Canada (n = 490 cases and 896 controls).
View Article and Find Full Text PDFBackground: In the causal mediation analysis framework, several parametric regression-based approaches have been introduced in past years for decomposing the total effect of an exposure on a binary outcome into a direct effect and an indirect effect through a target mediator. In this context, a well-known strategy involves specifying a logistic model for the outcome and invoking the rare outcome assumption (ROA) to simplify estimation. Recently, exact estimators for natural direct and indirect effects have been introduced to circumvent the challenges prompted by the ROA.
View Article and Find Full Text PDFObjective: To assess the association between childhood body fatness and epithelial ovarian cancer (EOC), and whether this association differs by type of EOC.
Methods: Using data from a population-based case-control study (497 cases and 902 controls) in Montreal, Canada conducted 2011-2016, we examined the association between childhood body fatness and EOC, overall and separately for invasive vs. borderline EOCs.
Purpose: To investigate the association between alcohol intake over the lifetime and the risk of overall, borderline, and invasive ovarian cancer.
Methods: In a population-based case-control study of 495 cases and 902 controls, conducted in Montreal, Canada, average alcohol intake over the lifetime and during specific age periods were computed from a detailed assessment of the intake of beer, red wine, white wine and spirits. Multivariable logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for the association between alcohol intake and ovarian cancer risk.
Vitamin D Exposure and Ovarian Cancer Risk and Prognosis.
Int J Environ Res Public Health
February 2020
Article Synopsis
- Ovarian cancer has a poor outlook, making it crucial to understand modifiable risk factors for prevention and better prognosis, with Vitamin D being one of the factors of interest in research.* ! -
- A systematic review of 17 studies on Vitamin D and ovarian cancer found mixed results, with some suggesting that higher sun exposure and dietary Vitamin D may be linked to lower cancer risk, but overall findings were inconsistent.* ! -
- Currently, evidence indicates that Vitamin D does not have a significant impact on ovarian cancer risk or survival, and future studies should comprehensively assess Vitamin D exposure across different sources and important time periods.* !