neuroAIx-Framework: design of future neuroscience simulation systems exhibiting execution of the cortical microcircuit model 20× faster than biological real-time.

Introduction: Research in the field of computational neuroscience relies on highly capable simulation platforms. With real-time capabilities surpassed for established models like the cortical microcircuit, it is time to conceive next-generation systems: neuroscience simulators providing significant acceleration, even for larger networks with natural density, biologically plausible multi-compartment models and the modeling of long-term and structural plasticity.

Methods: Stressing the need for agility to adapt to new concepts or findings in the domain of neuroscience, we have developed the neuroAIx-Framework consisting of an empirical modeling tool, a virtual prototype, and a cluster of FPGA boards.