Publications by authors named "Kevin J Westbrook"
Article Synopsis
- The study investigated the genomic diversity and antibiotic susceptibilities of Enterococcus faecalis from patients with infective endocarditis (IE).
- The researchers collected 60 E. faecalis isolates and used whole-genome sequencing and pharmacokinetic models to analyze their antibiotic resistance, notably to ampicillin and ceftriaxone.
- Results indicated that a significant portion of isolates (35%) belonged to two specific lineages (ST6 and ST179) associated with increased resistance, especially in ST6, highlighting the need for alternative antibiotic combinations for effective treatment.
spp. are opportunistic pathogens that cause nosocomial infections. Bacteriophages could be used to treat antibiotic-resistant infections.
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- Bacteriophage therapy shows promise as an alternative to antibiotics, but more characterized phages are needed.
- Researchers collected 23 bacterial isolates related to cystic fibrosis and clinical infections and isolated over a dozen phages from hospital wastewater.
- They characterized these phages using genomic techniques and tested their effectiveness against bacterial mutants and biofilms, highlighting the potential for tailored bacteriophage treatments.