Oral Antibiotic Use in Adulthood and Risk of Early-Onset Colorectal Cancer: A Case-Control Study.

Background And Aims: Prior antibiotic use may be a factor in the rising incidence of colorectal cancer seen in those under 50 years of age (early-onset colorectal cancer [EOCRC]); however, the few studies to examine this link have reported conflicting results. Therefore, we evaluated the association between oral antibiotic use in adulthood and EOCRC in a large integrated healthcare system in the United States.

Methods: A population-based nested case-control study was conducted among Kaiser Permanente Northern California patients 18-49 years of age diagnosed with EOCRC (adenocarcinoma of the colon or rectum) in 1998-2020 who had ≥2 years of continuous pharmacy benefit prior to diagnosis.

Access to healthy food stores modifies effect of a dietary intervention.

Background: Recent evidence suggests that opening a grocery store in a food desert does not translate to better diet quality among community residents.

Purpose: This study evaluated the influence of proximity to a healthy food store on the effect of a dietary behavioral intervention on diet among obese adults randomized to either a high fiber or American Heart Association diet intervention.

Methods: Participants were recruited from Worcester County, Massachusetts, between June 2009 and January 2012.

Barbara Hepworth and the tonsillectomy.

The Garnett Passe and Rodney Williams Foundation, a major medical research foundation in Melbourne, has recently acquired a hitherto unknown and uncatalogued painting by Dame Barbara Hepworth, the celebrated British sculptor and artist. It is of the Foundation's nominal patron Garnett Passe performing a tonsillectomy, probably at the London Clinic, in 1948. This article gives an account of Barbara Hepworth and her relationships with Garnett Passe and Norman Capener, the two surgeons who introduced her to this subject and who led to the creation of this unique work of art.

Incidental magnetic resonance image sinus abnormalities in asymptomatic Australian children.

Plain X-rays, computed tomography (CT) and magnetic resonance imaging (MRI) scans performed for non-ENT reasons often reveal incidental sinus mucosal changes. These changes need to be correlated clinically before diagnosing rhinosinusitis. This study examined the prevalence of such changes in MRI scans in children up to age 16.

Screening for dementia in "real world" settings: the cognitive assessment screening test: CAST.

Among elderly people who do not present with complaints of memory impairment, dementia is often missed by physicians, and time-consuming screening tests requiring expertise to administer and interpret are rarely done. Easily administered, reliable and cost effective dementia screening tests are needed for elderly individuals. The "pencil and paper" Cognitive Assessment Screening Test (CAST) takes minimal examiner time/training, and is both sensitive and specific in discriminating demented patients from healthy controls.