Publications by authors named "Kevin J Ho"
Front Cell Dev Biol
June 2019
Article Synopsis
- TET2 is a tumor suppressor gene that, when inactivated, is linked to various hematological cancers and plays a key role in DNA demethylation by converting 5-mC to 5-hmC.
- The gene has three identified promoters (Pro1, Pro2, Pro3) that produce alternative first exons, with expression varying based on cell type and developmental stage, and showing higher levels in tissues with hematopoietic stem cells like the spleen and bone marrow.
- Pro2 transcripts are the most widely expressed, while Pro3 is notably present in embryoid bodies but produces a truncated TET2 protein, indicating unique transcriptional regulation mechanisms in both stem cells and differentiated cells.
