Effect of tapped density, compacted density, and drug concentration on light-induced fluorescence response as a process analytical tool.

The effect of tapped density, compacted density, and fluorescent drug concentration on the light-induced fluorescence (LIF) response is reported. The fluorescent response to powder mixtures containing 0.25%-10.

Rapid at-line pharmaceutical cleaning verification using a novel light induced fluorescence (LIF) sensor.

A novel light emitting diode (LED) array-based light induced fluorescence (LIF) sensor is presented as an analytical methodology for at-line cleaning verification within the pharmaceutical industry. This sensor differs from conventional LIF sensors through the ability to dynamically control both the LED excitation array and detection parameters, enabling the exploitation of the optical power and detection sensitivity to rapidly detect trace concentrations of residual drug. This feature makes this sensor an ideal alternative to conventional cleaning verification analytical methodologies.

Monitoring powder blend homogeneity using light-induced fluorescence.

Light-induced fluorescence (LIF) was evaluated as a process analytical technology to monitor blend homogeneity and establish a relationship with high-performance liquid chromatography (HPLC). Secondary aims for this study included a determination of blend steady-state, acceptable mixing time interval, and mixing end point. Also, identification of potential "dead spots" in the 124 L intermediate bulk container mixing tote was explored.