Reporting stAndards for research in PedIatric Dentistry (RAPID): an expert consensus-based statement.

Background: Reporting guidelines for different study designs are currently available to report studies with accuracy and transparency. There is a need to develop supplementary guideline items that are specific to areas within Pediatric Dentistry. This study aims to develop Reporting stAndards for research in PedIatric Dentistry (RAPID) guidelines using a pre-defined expert consensus-based Delphi process.

Prospective randomized clinical trial of primary molar crowns: 36-month results.

Purpose: To clinically evaluate the clinical success of a primary zirconia molar crown, compared with stainless steel crowns (SSCs).

Methods: This randomized, controlled clinical trial was designed as a split-mouth study. 50 subjects ranging in age from 3-7 years were recruited to provide a total of 50 paired teeth requiring primary molar crowns, each participant receiving a SSC and zirconia crown.

Survival of Zirconia Crowns in Primary Maxillary Incisors at 12-, 24- and 36-Month Follow-Up.

The purpose of this study was to assess the survival probability of zirconia crowns (ZCs) on primary maxillary incisors placed in children diagnosed with severe early childhood caries at 12-, 24-, and 36-month follow-up visits in a university pediatric dental clinic. Ninety-four teeth in 30 healthy 24- to 60-month-olds who received ZCs under general anesthesia participated in this study ( equals 94). Data included children's demographics, dental-related variables, appointment dates, survival of crown, and type of failure (defined as replacement of lost ZCs or extraction of the treated tooth due to evidence of apical periodontitis prior to natural exfoliation).

Hidden Caries: A Case Report of a 17 Years Old Male with Two Affected Mandibular Premolars.

Hidden caries is the term used to describe carious lesions that are not visualized clinically on erupted teeth but can be detected radiographically. The exact etiology remains an area of controversy. The purpose of the current case report was to discuss the diagnosis and treatment of two mandibular premolars with hidden caries.

Reporting stAndards for research in PedIatric Dentistry (RAPID): A development protocol.

Reporting guidelines can improve the quality of reports of research findings. Some specialities in health care however require guidance on areas that are not captured within the existing guidelines, and this is the case for Paediatric Dentistry where no such standards are available to guide the reporting of different types of study designs. The 'Reporting stAndards for research in PedIatric Dentistry' (RAPID) group aims to address this need by developing guidelines on reporting elements of research of particular relevance to Paediatric Dentistry.

Early childhood caries epidemiology, aetiology, risk assessment, societal burden, management, education, and policy: Global perspective.

Background: This paper is a summary of the proceedings of the International Association of Paediatric Dentistry Bangkok Conference on early childhood caries (ECC) held in 3-4 November 2018.

Aim: The paper aims to convey a global perspective of ECC definitions, aetiology, risk factors, societal costs, management, educational curriculum, and policy.

Design: This global perspective on ECC is the compilation of the state of science, current concepts, and literature regarding ECC from worldwide experts on ECC.

Prospective Randomized Clinical Trial of Primary Molar Crowns: 24-Month Results.

The purpose of this study was to evaluate the clinical success of a new primary zirconia molar crown compared with stainless steel crowns (SSCs). This randomized, controlled clinical trial was designed as a split-mouth study. Fifty three- to seven-year-old children were recruited to provide a total of 50 pairs of teeth requiring primary molar crowns, with each participant receiving a SSC and zirconia crown.

Dentin and enamel demineralization inhibition at restoration margins of Vitremer, Z 100 and Cention N.

Purpose: To examine the in vitro caries inhibition of a resin-modified glass-ionomer cement, and a fluoride and calcium releasing resin-based composite.

Methods: Standardized Class V preparations were placed in 30 molars, the gingival margin placed below the cemento-enamel junction. Randomly, 10 Vitremer, 10 Z 100 and 10 Cention N restorations were placed according to manufacturer's instructions, in 30 teeth.

Fluoride release and re-release from a bioactive restorative material.

Purpose: To compare the amount of fluoride release and re-release of three different restorative materials.

Methods: The three restorative materials included a resin-based composite (Z100TM, 3M-ESPE), a resin-modified glass ionomer cement (VitremerTM, 3M-ESPE) and a bioactive material (Activa Bioactive-RestorativeTM, Pulpdent,). Ten disks were fabricated from each material.

Fluoride release and re-release from various esthetic restorative materials.

Purpose: To measure the amount of fluoride release and re-release after re-charge from two commonly used esthetic restorative materials and compare it to a new experimental material.

Methods: 30 standardized disc-shaped specimens were fabricated using resin-based composite (Z100), resin-modified glass-ionomer cement (Vitremer) and a new experimental material which is a self-curing resin-based composite with light curing option. 10 specimens were made from each material.

Dentin sialoprotein facilitates dental mesenchymal cell differentiation and dentin formation.

Dentin sialoprotein (DSP) is a dentin extracellular matrix protein. It is involved in dental mesenchymal cell lineages and dentin formation through regulation of its target gene expression. DSP mutations cause dentin genetic diseases.

Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo.

Dentin sialoprotein (DSP) is essential for dentinogenesis and processed into fragments in the odontoblast-like cells and the tooth compartments. Matrix metalloproteinase 9 (MMP9) is expressed in teeth from early embryonic to adult stage. Although MMP9 has been reported to be involved in some physiological and pathological conditions through processing substrates, its role in tooth development and whether DSP is a substrate of MMP9 remain unknown.

Retrospective Study of Retention of Stainless Steel Crowns and Pre-veneered Crowns on Primary Anterior Teeth.

Purpose: The purpose of this retrospective chart review was to explore the retention of anterior pre-veneered stainless steel crowns (NuSmile) and conventional stainless steel crowns (3M ESPE) placed on primary anterior teeth.

Methods: Records for children were reviewed over four years using the electronic record system axiUm. Data collected included child's age at time of crown placement, date of placement, tooth number, type of crown, patient behavior, treatment environment, provider type, crown presence, absence, and cementation success or failure at subsequent recall visits.

Establishment of Immortalized BMP2/4 Double Knock-Out Osteoblastic Cells Is Essential for Study of Osteoblast Growth, Differentiation, and Osteogenesis.

Bone morphogenetic proteins 2 and 4 (BMP2/4) are essential for osteoblast differentiation and osteogenesis. Generation of a BMP2/4 dual knock-out ((ko/ko)) osteoblastic cell line is a valuable asset for studying effects of BMP2/4 on skeletal development. In this study, our goal was to create immortalized mouse deleted BMP2/4 osteoblasts by infecting adenoviruses with Cre recombinase and green fluorescent protein genes into immortalized murine floxed BMP2/4 osteoblasts.

Space loss following premature loss of primary second molars.

This study was designed to evaluate the amount of space loss (SL) caused by premature loss of primary second molars, determine whether the eruption status of permanent first molars is an important factor in the amount of SL, and evaluate the effectiveness of space maintainers (SMs) in SL prevention. SL associated with 100 prematurely extracted primary second molars was evaluated in 87 healthy patients. Teeth were divided into groups based on the use of SMs (36 with SM and 64 without SM).

Establishment of Immortalized Mouse Bmp2 Knock-Out Dental Papilla Mesenchymal Cells Necessary for Study of Odontoblastic Differentiation and Odontogenesis.

Bmp2 is essential for dentin formation. Bmp2 cKO mice exhibited similar phenotype to dentinogenesis imperfecta, showing dental pulp exposure, hypomineralized dentin, and delayed odontoblast differentiation. As it is relatively difficult to obtain lot of primary Bmp2 cKO dental papilla mesenchymal cells and to maintain a long-term culture of these primary cells, availability of immortalized deleted Bmp2 dental papilla mesenchymal cells is critical for studying the underlying mechanism of Bmp2 signal in odontogenesis.

The Use of Resin-based Composite in Children: An Update.

Resin-based composites are an integral component of contemporary pediatric restorative dentistry. They can be utilized effectively for preventive resin restorations, moderate Class II restorations, Class III restorations, Class IV restorations, Class V restorations, and strip crowns. Tooth isolation to prevent contamination is a critical factor, and high-risk children may not be ideal candidates for resin-based composite restorations.

Dentin-enamel adhesives in pediatric dentistry: an update.

Adhesives and composite technology have made composite resins and polyacid-modified resin-based composites (compomers) very popular as materials to restore primary and permanent anterior and posterior teeth. More conservative preparations can be performed that maintain more tooth structure due to the adhesive properties of the adhesives used with composites and compomers. Meticulous care in the placement of adhesives and, subsequently, resin-based composites and compomers is necessary to produce long-term satisfactory results.

Dental sealants guidelines development: 2002-2014.

The purpose of this paper was to review the chronology of dental sealant guideline developments and changes in recommendations regarding sealant usage by various state, national, and international organizations between 2002 and 2014. More specific objectives include: (1) review and summarize the findings of systematic evidence-based reviews and recommendations regarding the use of pit and fissure sealants published since the 2002 American Academy of Pediatric Dentistry Pediatric Restorative Dentistry Consensus Conference; (2) identify consistencies and changes in conclusions or recommendations regarding the use of pit and fissure sealants, and differences in the methods used to develop recommendations/guidelines over time; and (3) describe the purpose and scope of current efforts to update American Dental Association 2008 Evidence-based Clinical Recommendations for the Use of Pit and Fissure Sealants. A summary of recommendations based on experts' synthesis of published evidence and recommendations is included.

Dental repair material: a resin-modified glass-ionomer bioactive ionic resin-based composite.

This report documents treatment and repair of three carious teeth that were restored with a new dental repair material that features the characteristics of both resin-modified glass-ionomer restorative cement (RMGI) and resin-based composite (RBC). The restorative products presented are reported by the manufacturer to be the first bioactive dental materials with an ionic resin matrix, a shock-absorbing resin component, and bioactive fillers that mimic the physical and chemical properties of natural teeth. The restorative material and base/liner, which feature three hardening mechanisms, could prove to be a notable advancement in the adhesive dentistry restorative materials continuum.