Thiosulfate: a readily accessible source of hydrogen sulfide in oxygen sensing.

H2S derived from organic thiol metabolism has been proposed serve as an oxygen sensor in a variety of systems because of its susceptibility to oxidation and its ability to mimic hypoxic responses in numerous oxygen-sensing tissues. Thiosulfate, an intermediate in oxidative H2S metabolism can alternatively be reduced and regenerate H2S. We propose that this contributes to the H2S-mediated oxygen-sensing mechanism.

A meta-analysis of the efficacy of anodal transcranial direct current stimulation for upper limb motor recovery in stroke survivors.

Study Design: Systematic review and meta-analysis.

Introduction: Prior reviews on the effects of anodal transcranial direct current stimulation (a-tDCS) have shown the effectiveness of a-tDCS on corticomotor excitability and motor function in healthy individuals but nonsignificant effect in subjects with stroke.

Purpose: To summarize and evaluate the evidence for the efficacy of a-tDCS in the treatment of upper limb motor impairment after stroke.

Superior humeral head migration occurs after a protocol designed to fatigue the rotator cuff: a radiographic analysis.

Hypothesis: Awkward postures and repetitive work have been suggested to lead to shoulder fatigue, which may in turn decrease the subacromial space. The aim of this study was to quantify changes in humeral head position relative to the glenoid after rotator cuff fatigue. We hypothesized that the humeral head would migrate superiorly with fatigue due to the inability of the rotator cuff muscles to balance the upward pull of the deltoid.

Synthesis of (-)-DAPD.

A new synthesis of (-)-DAPD, suitable for large scale development, is described.