Publications by authors named "Kevin Hochstrasser"
Unlabelled: Restless legs syndrome (RLS) and periodic limb movements of sleep (PLMS) have been variably implicated in risk for cardiovascular disease (CVD), but there is lack of consensus on these relationships. We sought to assess subclinical CVD measures and RLS/PLMS in a large cohort to further evaluate these associations. The Emory Center for Health Discovery and Well Being cohort is composed of employed adults, with subclinical CVD measures including endothelial function (flow-mediated vasodilation), microvascular function (reactive hyperemia index, RHI), arterial stiffness (pulse wave velocity and augmentation index), and carotid intima-media thickness (cIMT).
View Article and Find Full Text PDFAlthough new instructional technologies have been widely adopted, cognitive load theory (CLT) is rarely used to inform deployment of those technologies. This scoping review of published literature examined CLT use in the design of teaching technologies for medical students. Three databases were queried, and thematic characteristics were extracted.
View Article and Find Full Text PDFArticle Synopsis
- - Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in the TSC1 or TSC2 genes, leading to excessive activation of the mTOR pathway.
- - Individuals with TSC often experience various issues, including epilepsy, intellectual disability, autism, and sleep disorders, and studies show that mouse models exhibit disrupted circadian rhythms.
- - Research indicates that the protein BMAL1 is affected by mTOR regulation, resulting in abnormal levels and function that impact circadian rhythm; reducing BMAL1 levels can improve these rhythmic issues in TSC models.