Publications by authors named "Kevin He Liu"
Article Synopsis
- The study analyzes the mammary epithelium using single-cell RNA profiling across four developmental stages in mice, highlighting significant changes in gene expression.
- The research identifies a shift from a homogeneous basal-like gene expression in pre-puberty to distinct lineage-restricted programs during puberty.
- Additionally, it reveals various cell populations, including an early progenitor subset marked by CD55, a luminal transit population, and a rare mixed-lineage cluster, indicating a complex developmental hierarchy within the mammary gland.
Despite accumulating evidence for a mammary differentiation hierarchy, the basal compartment comprising stem cells remains poorly characterized. Through gene expression profiling of Lgr5 basal epithelial cells, we identify a new marker, Tetraspanin8 (Tspan8). Fractionation based on Tspan8 and Lgr5 expression uncovered three distinct mammary stem cell (MaSC) subsets in the adult mammary gland.
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