Brolucizumab for persistent macular fluid in neovascular age-related macular degeneration after prior anti-VEGF treatments.

Background: Some patients with neovascular age-related macular degeneration (nAMD) have persistent intraretinal/subretinal fluid (IRF/SRF) despite being treated with anti-VEGF agents. There is limited data on efficacy of switching to intravitreal brolucizumab (IVBr) in these patients.

Purpose: To determine anatomic and visual outcomes of eyes with nAMD treated with for persistent IRF/SRF.

ACUTE MACULAR NEURORETINOPATHY WITHOUT NEAR-INFRARED REFLECTANCE-AN ATYPICAL CASE PRESENTATION.

Background: Acute macular neuroretinopathy is a rare disease that with the help of multimodal imaging is being diagnosed more frequently.

Methods: An atypical case is presented and followed by multimodal imaging.

Results: A typical acute macular neuroretinopathy lesion was seen on biomicroscopic examination and spectral domain optical coherence tomography examination.

RETINAL ARTERIOVENOUS MALFORMATION.

Purpose: To describe a case of an isolated Group 3 retinal arteriovenous malformation (AVM).

Methods: Observational case report.

Results: A 15-year-old girl with no significant medical history presented with no light perception vision in her right eye and gradually decreasing vision in her left eye over several years.

SUSAC SYNDROME.

Purpose: To describe an atypical presentation of Susac syndrome.

Methods: Observational case report.

Results: A 44-year-old man with no significant medical history presented with inferonasal visual field loss in his left eye of several months of duration.

Expression, purification, crystallization and preliminary X-ray analysis of the receiver domain of Staphylococcus aureus LytR protein.

The response-regulatory protein LytR belongs to a family of transcription factors involved in the regulation of important virulence factors in pathogenic bacteria. The protein consists of a receiver domain and an effector domain, which play an important role in controlled cell death and lysis. The LytR receiver domain (LytR(N)) has been overexpressed, purified and crystallized using the sitting-drop and hanging-drop vapour-diffusion methods.

Effect of hemodialysis on intraocular pressure and ocular perfusion pressure.

Importance: Elevated intraocular pressure (IOP) and decreased ocular perfusion pressure (OPP) are risk factors for glaucoma development and progression. Unrecognized significant IOP elevation or OPP reduction during hemodialysis (HD) could lead to glaucomatous optic nerve damage and subsequent visual loss.

Objective: To evaluate changes in IOP and OPP during HD.

Simplified universal method for determining electrolyte temperatures in a capillary electrophoresis instrument with forced-air cooling.

Temperature increase due to resistive electrical heating is an inherent limitation of capillary electrophoresis (CE). Active cooling systems are used to decrease the temperature of the capillary, but their capacity is limited; and in addition, they leave "hot spots" at the detection interface and at the capillary ends. Until recently, the matter was complicated by the lack of a fast and generic method for temperature determination in efficiently and inefficiently cooled regions of the capillary.

Presentation and outcome of patients with punctate inner choroidopathy at a tertiary referral center.

Purpose: To describe the clinical course of patients with punctate inner choroidopathy seen at the University of Illinois, with emphasis on development of choroidal neovascularization (CNV).

Methods: Patients with a diagnosis of punctate inner choroidopathy were identified retrospectively. The diagnosis was made clinically based on findings of multiple, small "punched-out" lesions in the posterior pole without intraocular inflammation.