Publications by authors named "Kevin Gorrichon"
Article Synopsis
- - Centrioles are key structures in centrosomes that help organize cell division by managing the assembly of the mitotic spindle and chromosome separation in animal cells.
- - In sexually reproducing species, centrioles degenerate during female meiosis but are retained and reintroduced during male meiosis and fertilization, while their role in parthenogenetic (asexual) species is less understood.
- - Research shows that in two asexual parthenogenetic nematode species, centrioles are maternally inherited, with different strategies affecting how they organize meiotic spindles and contribute to embryo development, functioning similarly to sperm-derived centrioles in sexually reproducing species.
Article Synopsis
- Long-read sequencing (LRS) technologies have advanced significantly, overcoming initial technical limitations and improving in read length, throughput, and accuracy.
- The review highlights recent impactful discoveries enabled by LRS, including high-resolution genome and transcriptome sequencing, as well as the detection of DNA and RNA modifications.
- LRS methods are poised to enhance our understanding of human genetic variation, transcriptomics, and epigenetics in the near future.
With its nuclear dualism, the ciliate constitutes a unique model to study how host genomes cope with transposable elements (TEs). harbors two germline micronuclei (MICs) and a polyploid somatic macronucleus (MAC) that develops from one MIC at each sexual cycle. Throughout evolution, the MIC genome has been continuously colonized by TEs and related sequences that are removed from the somatic genome during MAC development.
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- The text refers to a correction made to an existing article published with the DOI 10.3389/fcimb.2021.761945.
- The correction addresses errors or inaccuracies in the original article to ensure the information is accurate and reliable.
- This type of amendment is important in academic publishing to maintain the integrity of the research and provide readers with trustworthy content.
An Immunomodulatory Transcriptional Signature Associated With Persistent Infection in Hepatocytes.
Front Cell Infect Microbiol
January 2022
causes severe foodborne illness in pregnant women and immunocompromised individuals. After the intestinal phase of infection, the liver plays a central role in the clearance of this pathogen through its important functions in immunity. However, recent evidence suggests that during long-term infection of hepatocytes, a subpopulation of may escape eradication by entering a persistence phase in intracellular vacuoles.
View Article and Find Full Text PDFBacteria of the genus Streptomyces are prolific producers of specialized metabolites, including antibiotics. The linear chromosome includes a central region harboring core genes, as well as extremities enriched in specialized metabolite biosynthetic gene clusters. Here, we show that chromosome structure in Streptomyces ambofaciens correlates with genetic compartmentalization during exponential phase.
View Article and Find Full Text PDFDendritic cell-derived exosomes (Dex) are nanovesicles bearing major histocompatibility complexes promoting T-cell-dependent antitumor effects in mice. Two phase I clinical trials aimed at vaccinating cancer patients with peptide-pulsed Dex have shown the feasibility and safety of inoculating clinical-grade Dex, but have failed to show their immunizing capacity. These low immunogenic capacities have led us to develop second-generation Dex with enhanced immunostimulatory properties.
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